Details

scope
Mouse cortex recurrent network models with PYR, PV, SST, VIP populations; theoretical and numerical analysis
claim_text
In four-population (PYR, PV, SST, VIP) network models, the paradoxical effect upon PV photo-excitation can occur even when the network is not inhibition-stabilized, complicating the inference of ISN regime from paradoxical responses.
section_id
section_09
source_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json
effect_size
paradoxical effect in 4-pop network can occur outside ISN regime (qualitative, derived analytically)
review_repo
ComputationalReviewRecurrence
section_ref
wiki_page:computationalreviewrecurrence-09-amplification-isn
source_kind
review_finding
source_path
evidence/section_09_evidence_package.json
source_span
Here we show that in contrast, in four-population networks, the paradoxical effect can occur even if the network is not inhibition stabilized.
study_system
Mouse cortex recurrent network models with PYR, PV, SST, VIP populations; theoretical and numerical analysis
section_title
9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation
evidence_summary
Mathematical analysis and simulations of mouse cortical four-population recurrent networks with PV, SST, VIP interneuron classes; comparison to two-population network theory.
review_bundle_ref
analysis_bundle:ab-d9c479db9be9
replication_status
within_lab
review_package_ref
analysis_bundle:ab-d9c479db9be9
source_artifact_ref
wiki_page:computationalreviewrecurrence-09-amplification-isn
origin_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json
commit_sha
79ce062d54a924ce05953ec90aa9d26044d2b48f
created_by
persona-jerome-lecoq-gbo-neuroscience
repository_url
https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (4)
raw_fields
{
  "n": 0,
  "doi": "10.7554/elife.49967",
  "claim": "In four-population (PYR, PV, SST, VIP) network models, the paradoxical effect upon PV photo-excitation can occur even when the network is not inhibition-stabilized, complicating the inference of ISN regime from paradoxical responses.",
  "cite_key": "Mahrach2020",
  "evidence": "Mathematical analysis and simulations of mouse cortical four-population recurrent networks with PV, SST, VIP interneuron classes; comparison to two-population network theory.",
  "effect_size": "paradoxical effect in 4-pop network can occur outside ISN regime (qualitative, derived analytically)",
  "text_access": "fulltext",
  "study_system": "Mouse cortex recurrent network models with PYR, PV, SST, VIP populations; theoretical and numerical analysis",
  "argument_role": "supporting",
  "replication_status": "within_lab",
  "claim_source_sentence": "Here we show that in contrast, in four-population networks, the paradoxical effect can occur even if the network is not inhibition stabilized.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}
source_refs
[
  "paper:paper-38fe71bdf9b6"
]
evidence_refs
[
  {
    "ref": "paper:paper-38fe71bdf9b6"
  }
]
source_policy
{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}

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