Single-neuron burst stimulation in mouse V1 in vivo can drive spiking in both e…

Single-neuron burst stimulation in mouse V1 in vivo can drive spiking in both excitatory and inhibitory neurons within ~100 μm, with ~30% of SST interneurons firing reliably to a single presynaptic burst — direct in vivo evidence of measurable recurrent influence from individual pyramidal cells in mouse cortex.

{
  "n": 0,
  "doi": "10.1016/j.cub.2012.06.007",
  "claim": "Single-neuron burst stimulation in mouse V1 in vivo can drive spiking in both excitatory and inhibitory neurons within ~100 μm, with ~30% of SST interneurons firing reliably to a single presynaptic burst — direct in vivo evidence of measurable recurrent influence from individual pyramidal cells in mouse cortex.",
  "cite_key": "Kwan2012",
  "evidence": "Two-photon calcium imaging of mouse V1 ensemble with simultaneous targeted patch stimulation of a single pyramidal neuron; molecular identification of SST and PV interneurons.",
  "effect_size": "~30% of SST interneurons fire reliably to a single presynaptic burst of ≥5 spikes; PV interneurons show no detectable single-neuron response",
  "text_access": "abstract_only",
  "study_system": "Mouse V1 in vivo, two-photon imaging + targeted patch stimulation",
  "argument_role": "supporting",
  "replication_status": "within_lab",
  "claim_source_sentence": "Burst spiking of a single pyramidal neuron can drive spiking activity in both excitatory and inhibitory neurons within a ∼100 μm radius.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "For inhibitory neurons, ∼30% of the somatostatin interneurons fire reliably in response to a presynaptic burst of ≥5 spikes."
}

[
  "paper:paper-a6560ae29416"
]

[
  {
    "ref": "paper:paper-a6560ae29416"
  }
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
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