- claim_text
Optogenetic modulation of even a minor fraction of PV interneurons in mouse barrel cortex produces broad-spectrum power changes in spontaneous and sensory-evoked activity, consistent with strong recurrent E→E coupling stabilized by inhibition.
- raw_fields
{
"n": 0,
"doi": "10.1093/cercor/bhx261",
"claim": "Optogenetic modulation of even a minor fraction of PV interneurons in mouse barrel cortex produces broad-spectrum power changes in spontaneous and sensory-evoked activity, consistent with strong recurrent E→E coupling stabilized by inhibition.",
"cite_key": "Yang2017",
"evidence": "Optogenetic activation and inhibition of PV interneurons in mouse barrel cortex with in vivo extracellular recording during spontaneous and whisker-evoked activity.",
"effect_size": "~10% of local PV population modulated produces widespread network effects",
"text_access": "abstract_only",
"study_system": "Mouse barrel cortex (S1), in vivo extracellular + optogenetic PV manipulation",
"argument_role": "supporting",
"replication_status": "within_lab",
"claim_source_sentence": "Histological assessment of transduced cells combined with quantitative modeling of light distribution and spike sorting revealed that only a minor fraction (~10%) of the local PV population comprising no more than a few hundred neurons is optogenetically modulated, mediating the observed prominent and widespread effects on neocortical processing.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": "Inversely, activating PV interneurons drastically decreased spontaneous and whisker-evoked activity in the principal column and exerted strong lateral inhibition."
}- source_refs
[
"paper:paper-f450ef113660"
]
- source_span
Histological assessment of transduced cells combined with quantitative modeling of light distribution and spike sorting revealed that only a minor fraction (~10%) of the local PV population comprising no more than a few hundred neurons is optogenetically modulated, mediating the observed prominent and widespread effects on neocortical processing.
- evidence_refs
[
{
"ref": "paper:paper-f450ef113660"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}