- claim_text
All ventral-eminence-derived cortical interneurons (including CGE-derived) undergo programmed cell death, but in contrast to MGE/PV/SST classes, VIP interneuron survival is NOT activity-dependent; Calcineurin in interneurons sequentially controls morphological maturation (E15–P5) and subsequent activity-dependent survival (P5–P20).
- raw_fields
{
"n": 0,
"doi": "10.1016/j.celrep.2018.01.007",
"claim": "All ventral-eminence-derived cortical interneurons (including CGE-derived) undergo programmed cell death, but in contrast to MGE/PV/SST classes, VIP interneuron survival is NOT activity-dependent; Calcineurin in interneurons sequentially controls morphological maturation (E15–P5) and subsequent activity-dependent survival (P5–P20).",
"title": null,
"cite_key": "Priya2018",
"evidence": "Cell-type-specific genetic and activity manipulations in mouse cortex with cell-death and morphology readouts.",
"effect_size": "qualitative — VIP interneurons are exception",
"text_access": "abstract_only",
"study_system": "mouse cortex",
"_source_cluster": "cluster_02_development_lineage",
"replication_status": "replication_unknown",
"_source_cluster_index": 76,
"claim_source_sentence": "Moreover, with the exception of VIP interneurons, this occurs in a manner that is activity-dependent.",
"replication_evidence_dois": [],
"effect_size_source_sentence": null
}- source_refs
[
"paper:paper-132ad38dffb8"
]
- evidence_refs
[
{
"ref": "paper:paper-132ad38dffb8"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}