Details
- scope
- human (MTG snRNA-seq) vs. mouse CGE literature
- section_id
- section_03
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
- effect_size
- Human CGE types lack HTR3A expression vs near-universal expression in mouse CGE-derived 5HT3aR group
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-03-development
- source_kind
- review_finding
- source_path
- evidence/section_03_evidence_package.json
- source_span
- Surprisingly, the mouse CGE interneuron marker HTR3A 38 was not expressed in human CGE types ( Fig. 3c ).
- study_system
- human (MTG snRNA-seq) vs. mouse CGE literature
- section_title
- Developmental Origins and Postnatal Maturation
- evidence_summary
- snRNA-seq of human MTG; cross-species marker comparison with published mouse cortex data; cell-type tree alignment via MetaNeighbor and conserved/divergent marker analysis.
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- primary
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-03-development
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_03_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
The mouse CGE marker HTR3A (5HT3aR) is NOT expressed in human CGE-lineage interneuron types, marking a major species-specific divergence in CGE molecular signature and indicating that mouse VIP/CGE markers cannot be transferred unchanged to human cortex.
- raw_fields
{ "n": null, "doi": "10.1038/s41586-019-1506-7", "claim": "The mouse CGE marker HTR3A (5HT3aR) is NOT expressed in human CGE-lineage interneuron types, marking a major species-specific divergence in CGE molecular signature and indicating that mouse VIP/CGE markers cannot be transferred unchanged to human cortex.", "title": null, "cite_key": "Hodge2019", "evidence": "snRNA-seq of human MTG; cross-species marker comparison with published mouse cortex data; cell-type tree alignment via MetaNeighbor and conserved/divergent marker analysis.", "effect_size": "Human CGE types lack HTR3A expression vs near-universal expression in mouse CGE-derived 5HT3aR group", "figure_data": [], "text_access": "fulltext", "study_system": "human (MTG snRNA-seq) vs. mouse CGE literature", "_source_cluster": "cluster_02_development_lineage", "replication_status": "primary", "_source_cluster_index": 101, "claim_source_sentence": "Surprisingly, the mouse CGE interneuron marker HTR3A 38 was not expressed in human CGE types ( Fig. 3c ).", "replication_evidence_dois": [], "effect_size_source_sentence": "Surprisingly, the mouse CGE interneuron marker HTR3A 38 was not expressed in human CGE types ( Fig. 3c )." }- source_refs
[ "paper:paper-pm-31435019" ]
- evidence_refs
[ { "ref": "paper:paper-pm-31435019" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }