Analysis reveals the structure of connectivity implied by various features of s…

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To test the robustness of our findings, we relax these assumptions and fit models so that the mix of 85% excitatory and 15% inhibitory cells match the perturbation response from ref., both as a function of distance and as a function of orientation tuning preference.

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Analysis reveals the structure of connectivity implied by various features of single-cell perturbation responses, such as the surprisingly narrow spatial radius of nearby excitation beyond which inhibition dominates, the number of transitions between mean excitation and inhibition thereafter, and the dependence of these responses on feature preferences.

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What are the principles that govern the responses of cortical networks to their inputs and the emergence of these responses from recurrent connectivity? Recent experiments have probed these questions by measuring cortical responses to two-photon optogenetic perturbations of single cells in the mouse primary visual cortex. A robust theoretical framework is needed to determine the implications of these responses for cortical recurrence. Here, we propose a formulation of the dependence of cell-type...