Details
- scope
- mouse; visual cortex, PFC; two-photon imaging, optogenetics; Nature communications
- claim_text
- Projection-specific two-photon calcium imaging and optogenetic manipulations show that ACC outputs to the superior colliculus, a key midbrain structure for response selection, principally coordinate…
- section_id
- section_09
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json
- effect_size
- It was then incubated in primary antibodies against GABA and NeuN (rabbit anti-GABA, 1:500, A2052 Sigma; guinea pig anti-NeuN, 1:500, 266-004 Synaptic Systems) and 1% NGS/0.5% triton overnight at 4 °C.
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-09-amplification-isn
- source_kind
- review_finding
- source_path
- evidence/section_09_evidence_package.json
- source_span
- Projection-specific two-photon calcium imaging and optogenetic manipulations show that ACC outputs to the superior colliculus, a key midbrain structure for response selection, principally coordinate specific motor responses.
- study_system
- mouse; visual cortex, PFC; two-photon imaging, optogenetics; Nature communications
- section_title
- 9. Physiological signature I — recurrent amplification of weak inputs in mouse cortex; balanced-amplification regimes; ISN operation
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- single_study
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-09-amplification-isn
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_09_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (5)
- raw_fields
{ "n": null, "doi": "10.1038/s41467-020-19772-z", "claim": "Projection-specific two-photon calcium imaging and optogenetic manipulations show that ACC outputs to the superior colliculus, a key midbrain structure for response selection, principally coordinate…", "cite_key": "Huda2020", "evidence": "Sensorimotor behaviors require processing of behaviorally relevant sensory cues and the ability to select appropriate responses from a vast behavioral repertoire. Modulation by the prefrontal cortex (PFC) is thought to be key for both processes, but the precise role of specific circuits remains unclear. We examined the sensorimotor function of anatomically distinct outputs from a subdivision of the mouse PFC, the anterior cingulate cortex (ACC). Using a visually guided two-choice behavioral para...", "effect_size": "It was then incubated in primary antibodies against GABA and NeuN (rabbit anti-GABA, 1:500, A2052 Sigma; guinea pig anti-NeuN, 1:500, 266-004 Synaptic Systems) and 1% NGS/0.5% triton overnight at 4 °C.", "text_access": "fulltext", "study_system": "mouse; visual cortex, PFC; two-photon imaging, optogenetics; Nature communications", "argument_role": "supporting", "replication_status": "single_study", "claim_source_sentence": "Projection-specific two-photon calcium imaging and optogenetic manipulations show that ACC outputs to the superior colliculus, a key midbrain structure for response selection, principally coordinate specific motor responses.", "source_provenance_status": "ok", "replication_evidence_dois": [], "claim_rewritten_from_source": true, "effect_size_source_sentence": "It was then incubated in primary antibodies against GABA and NeuN (rabbit anti-GABA, 1:500, A2052 Sigma; guinea pig anti-NeuN, 1:500, 266-004 Synaptic Systems) and 1% NGS/0.5% triton overnight at 4 °C." }- source_refs
[ "paper:paper-76648660797f" ]
- evidence_refs
[ { "ref": "paper:paper-76648660797f" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }- evidence_summary
Sensorimotor behaviors require processing of behaviorally relevant sensory cues and the ability to select appropriate responses from a vast behavioral repertoire. Modulation by the prefrontal cortex (PFC) is thought to be key for both processes, but the precise role of specific circuits remains unclear. We examined the sensorimotor function of anatomically distinct outputs from a subdivision of the mouse PFC, the anterior cingulate cortex (ACC). Using a visually guided two-choice behavioral para...