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"doi": "10.1371/journal.pcbi.1012036",
"claim": "We first demonstrate that thalamocortical feedforward (FF) and feedback (FB) stimuli arriving in the column have opposite effects, leading to net columnar excitation and inhibition respectively and r…",
"cite_key": "Moreni2025a",
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"effect_size": "At 700ms an constant input of 150 pA is injected to 25% of L4 pyramidal cells and 5% of PV cells.",
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"study_system": "mouse; V1; computational model, spiking network model; PLoS computational biology",
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We first demonstrate that thalamocortical feedforward (FF) and feedback (FB) stimuli arriving in the column have opposite effects, leading to net columnar excitation and inhibition respectively and revealing translaminar gain control via full-column inhibition by layer 6.
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Stimulation of specific cell groups under different network regimes (e.g., spontaneous activity or sensory-evoked activity) can provide insights into the neural dynamics of cortical columns. While these protocols are challenging to perform experimentally, modelling can serve as a powerful tool for such explorations. Using detailed electrophysiological and anatomical data from mouse V1, we built a novel spiking network model of a cortical column, which incorporates pyramidal cells and three disti...