VIP is the most transcriptomically diverse interneuron subclass in human middle…

VIP is the most transcriptomically diverse interneuron subclass in human middle temporal gyrus (21 types), with many VIP types enriched in upper layers and several closely related to a layer 1–2 LAMP5/PAX6 (L1 LAMP5 NMBR) type — indicating extensive intra-VIP molecular heterogeneity in human cortex.

{
  "n": null,
  "doi": "10.1038/s41586-019-1506-7",
  "claim": "VIP is the most transcriptomically diverse interneuron subclass in human middle temporal gyrus (21 types), with many VIP types enriched in upper layers and several closely related to a layer 1–2 LAMP5/PAX6 (L1 LAMP5 NMBR) type — indicating extensive intra-VIP molecular heterogeneity in human cortex.",
  "title": null,
  "cite_key": "Hodge2019",
  "evidence": "snRNA-seq of human MTG (8 donors, ~16,000 nuclei); 45 GABAergic types parsed; ADARB2-branch organization with LAMP5/PAX6 vs VIP subclasses.",
  "effect_size": "21 transcriptomically distinct VIP types in human MTG (vs fewer in mouse)",
  "figure_data": [
    {
      "type": "cell_type_count",
      "unit": "types",
      "value": 21,
      "metric": "Number of transcriptomic VIP types in human MTG",
      "source": "Hodge 2019 Fig. 3a",
      "context": "Most diverse interneuron subclass; many enriched in upper layers"
    }
  ],
  "text_access": "fulltext",
  "study_system": "human, MTG (adult, snRNA-seq)",
  "_source_cluster": "cluster_02_development_lineage",
  "replication_status": "primary",
  "_source_cluster_index": 100,
  "claim_source_sentence": "VIP was the most diverse subclass (21 types), with many types enriched in upper layers ( Fig. 3a ). Several VIP types were closely related to the LAMP5/PAX6 type L1 LAMP5 NMBR and localized to L1-L2.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "VIP was the most diverse subclass (21 types), with many types enriched in upper layers ( Fig. 3a )."
}

[
  "paper:paper-pm-31435019"
]

[
  {
    "ref": "paper:paper-pm-31435019"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}