Nuclear-localized GCaMP imaging in mouse V1 reveals 'micro-clustered' orientati…

Nuclear-localized GCaMP imaging in mouse V1 reveals 'micro-clustered' orientation organization — very close neuron pairs share orientation tuning strongly while distant pairs are randomly arranged — predicting spatially localized recurrent connectivity.

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  "n": 0,
  "doi": "10.1101/2025.02.11.637768",
  "claim": "Nuclear-localized GCaMP imaging in mouse V1 reveals 'micro-clustered' orientation organization — very close neuron pairs share orientation tuning strongly while distant pairs are randomly arranged — predicting spatially localized recurrent connectivity.",
  "cite_key": "Yu2025",
  "evidence": "In vivo two-photon calcium imaging of mouse V1 using a nuclear-localized GCaMP to reduce neuropil contamination; complemented by anatomical and optogenetic mapping consistent with localized recurrent connectivity.",
  "effect_size": "Spatial scale of strong tuning correlation confined to very nearby neurons; preserved despite salt-and-pepper map",
  "text_access": "abstract_only",
  "study_system": "mouse V1; two-photon calcium imaging with nuclear-localized GCaMP, anatomical and optogenetic circuit mapping",
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  "claim_source_sentence": "We found that the orientation tuning properties of distant neuron pairs () are irregularly and randomly organized, while neuron pairs that are extremely closehave strongly correlated orientation tuning, indicating a narrow yet strong spatially clustered organization of orientation preference, which we term 'micro-clustered' organization.",
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  "effect_size_source_sentence": "We found that the orientation tuning properties of distant neuron pairs () are irregularly and randomly organized, while neuron pairs that are extremely closehave strongly correlated orientation tuning, indicating a narrow yet strong spatially clustered organization of orientation preference, which we term 'micro-clustered' organization."
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We found that the orientation tuning properties of distant neuron pairs () are irregularly and randomly organized, while neuron pairs that are extremely closehave strongly correlated orientation tuning, indicating a narrow yet strong spatially clustered organization of orientation preference, which we term 'micro-clustered' organization.

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