Selective persistent delay activity that predicts upcoming licking direction is…

{
  "n": 295,
  "doi": "10.1038/nature22324",
  "claim": "Selective persistent delay activity that predicts upcoming licking direction is maintained in a frontal thalamocortical loop; photoinhibiting either ALM or thalamus collapses activity in the other and produces contralesional neglect.",
  "cite_key": "Guo2017",
  "evidence": "Spike recordings and unilateral optogenetic perturbation of mouse ALM and ventromedial/ventral-anterolateral thalamus during a tactile discrimination with delayed lick response.",
  "effect_size": "Reduction of thalALM spike rates to 67.8% of baseline during delay with TRN axonal photostimulation",
  "text_access": "fulltext",
  "study_system": "mouse ALM–VM/VAL thalamus (tactile delayed-response task)",
  "source_cluster_id": "cluster_05",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "Photoinhibition of the thalamus caused a short-latency and near-complete collapse of ALM activity.",
  "replication_evidence_dois": [
    "10.1038/nn.4568",
    "10.1038/nature22073"
  ],
  "effect_size_source_sentence": "Photostimulating axonal terminals of TRN GABAergic neurons in thalamus reduced spike rates in thal ALM (recorded near VM/VAL, to 67.8% during the delay epoch; Extended Data Fig."
}

[
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]

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  }
]

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