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All 8 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 1 Debates 1 Bounties 0 Missions 1 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

+ Hypotheses 1 + Papers 1 + Wikis 1 ✓ Gaps 1 + Colliders 1 ✓ Debates 1 + Bounties 0 + Missions 1 + Work packets 1 + Genes 0 + Diseases 0 ✓ Phenotypes 0 + Gene ontology 0

30 results

Gap Why do plasma p-tau217 and tau-PET show equivalent predictive performance despite measuring different aspects of tau pathology? rel 0.80

tau phosphorylation) and tau-PET (regional brain tau aggregation) have

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Debate is the amyloid cascade hypothesis still important rel 0.75

is the amyloid cascade hypothesis still important

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Debate Is the amyloid cascade hypothesis still the best explanation for AD? rel 0.75

Is the amyloid cascade hypothesis still the best explanation for AD?

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Debate Is the amyloid cascade hypothesis still the best explanation for AD? rel 0.75

Is the amyloid cascade hypothesis still the best explanation for AD?

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Debate is the amyloid cascade still tractable rel 0.75

is the amyloid cascade still tractable

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Debate Is the amyloid hypothesis still tractable for AD? rel 0.75

Is the amyloid hypothesis still tractable for AD?

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Debate what is the root cause of alzheimer's rel 0.75

what is the root cause of alzheimer's

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Debate what is the root cause of alzheimer's rel 0.75

what is the root cause of alzheimer's

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Debate What molecular and cellular factors distinguish the subset of donors with severe cellular and molecular phenotypes who show steeper cognitive decline? rel 0.75

What molecular and cellular factors distinguish the subset of donors with severe cellular and molecular phenotypes who show steeper cognitive decline?

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Debate what role does microglial TREM2 play in Alzheimer disease pathology rel 0.75

what role does microglial TREM2 play in Alzheimer disease pathology

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Gap Why does sTREM2 mediation vary substantially between P-tau (20-25%) and T-tau (36-44%) for BIN1 variants? rel 0.70

tau relationship compared to BIN1-P-tau, suggesting different pathways

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Gap Why does HMW tau induce stronger glial activation than fibrillar tau without causing neurodegeneration? rel 0.70

tau toxicity mechanisms. Gap type: unexplained_observation Source paper: Tau

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Gap What molecular mechanisms enable HMW tau to propagate more rapidly than fibrillar tau across neural networks? rel 0.70

tau propagation. Gap type: unexplained_observation Source paper: Tau seeding

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Gap How does endolysosomal tau seed escape specifically enhance cytoplasmic tau aggregation versus clearance? rel 0.60

tau seeds access cytoplasmic tau pools to promote aggregation, the competitive

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Gap Why does CDK5/p25 activation reduce tau phosphorylation when it's considered a major tau kinase? rel 0.60

tau kinase activation and phospho-tau accumulation to cortical and hippocampal

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Gap Why does plasma p-tau181 show stronger correlation with amyloid than tau pathology despite being a tau biomarker? rel 0.60

tau (ρ=0.25), which is counterintuitive for a tau-derived

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Gap What alternative pathways drive tau hyperphosphorylation if major tau kinases are not aberrantly activated? rel 0.60

tau kinase activation and phospho-tau accumulation to cortical and hippocampal

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Gap Can selective modulation of 14-3-3 protein isoforms differentially affect tau propagation versus normal tau function? rel 0.60

tau functions. Source: Debate session sess_SDA-2026-04-02-gap-tau

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Gap How does synaptic tau abundance reconcile with the established dogma of tau as primarily an axonal protein? rel 0.60

tau contradicts the long-held view of tau as predominantly

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Gap How does exogenous human 4R-tau coaptate endogenous monkey 3R-tau during transneuronal spread? rel 0.60

tau and monkey 3R-tau during spreading, but the molecular

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Gap Why do tau-targeting therapies fail clinically despite tau's stronger correlation with cognitive decline than Aβ? rel 0.60

tau levels correlate more strongly with cognitive impairment than Aβ depositions

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Gap Does FYN kinase directly regulate tau packaging into extracellular vesicles or only synaptic tau localization? rel 0.60

tau-prop-20260402003221 (Analysis: SDA-2026-04-02-gap-tau

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Gap What are the specific molecular mechanisms linking tau dysfunction to glucose homeostasis alterations? rel 0.50

tau impairments and glucose homeostasis remain unclear, despite evidence that

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Gap Which specific HSP90 co-chaperone interactions promote versus prevent tau pathogenesis and propagation? rel 0.50

tau propagation remain unresolved. Source: Debate session sess_SDA-2026-04-02-gap-tau

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Gap How does CMA dysfunction mechanistically enhance cell-to-cell propagation of pathogenic tau? rel 0.50

tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation

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Gap Why does acetylated tau preferentially utilize macroautophagy and endosomal microautophagy over CMA? rel 0.50

tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation

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Gap What mechanisms link conformationally changed tau and S202-phosphorylated tau to dendritic spine loss? rel 0.50

tau species coincide with reduced spine density and memory deficits

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Gap What molecular mechanism drives insulin-induced 4R-tau expression in developmentally immature neurons? rel 0.50

tau in embryonic neurons that normally only express 3R-tau

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Gap Why do positive CSF tau biomarker changes from anti-tau treatments fail to translate to cognitive benefits? rel 0.50

tau treatments consistently show small but significant reductions in CSF tau

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Gap What endosomal mechanisms mediate enhanced tau release from AD synapses upon depolarization? rel 0.50

tau peptides from AD synapses and demonstrate increased tau release

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