Details
- scope
- Awake male mouse, wS1; eOPN3 axonal inhibition
- claim_text
- In mouse whisker S1, optogenetic silencing of the whisker secondary somatosensory cortex (wS2) cortico-cortical input — but not whisker motor cortex (wM1) input — attenuates whisking-related sub- and supra-threshold dynamics.
- section_id
- section_08
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json
- effect_size
- Silencing wS2 (and wTLM thalamic) inputs largely attenuated whisking-related dynamics in wS1; wM1 silencing had no effect (qualitative).
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-08-cross-areal
- source_kind
- review_finding
- source_path
- evidence/section_08_evidence_package.json
- source_span
- Despite an extensive innervation, inhibition of inputs from the whisker primary motor cortex (wM1) to wS1 did not alter the spike rates anddynamics of wS1 neurons during whisking.
- study_system
- Awake male mouse, wS1; eOPN3 axonal inhibition
- section_title
- 8. Cross-areal mouse cortico-cortical excitatory connectivity — hierarchical feedforward and feedback as recurrent loops at the network level; Allen Mouse Connectivity Atlas anchored views
- evidence_summary
- Soma-targeted eOPN3 inhibition of specific long-range axons targeting wS1 in awake mice during whisking, with whole-cell and spike measurements.
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- single-study
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-08-cross-areal
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (4)
- raw_fields
{ "n": null, "doi": "10.1523/jneurosci.1148-23.2023", "claim": "In mouse whisker S1, optogenetic silencing of the whisker secondary somatosensory cortex (wS2) cortico-cortical input — but not whisker motor cortex (wM1) input — attenuates whisking-related sub- and supra-threshold dynamics.", "cite_key": "Kawatani2024", "evidence": "Soma-targeted eOPN3 inhibition of specific long-range axons targeting wS1 in awake mice during whisking, with whole-cell and spike measurements.", "effect_size": "Silencing wS2 (and wTLM thalamic) inputs largely attenuated whisking-related dynamics in wS1; wM1 silencing had no effect (qualitative).", "text_access": "abstract_only", "study_system": "Awake male mouse, wS1; eOPN3 axonal inhibition", "argument_role": "supporting", "replication_status": "single-study", "claim_source_sentence": "Despite an extensive innervation, inhibition of inputs from the whisker primary motor cortex (wM1) to wS1 did not alter the spike rates anddynamics of wS1 neurons during whisking.", "source_provenance_status": "non_substring_match", "replication_evidence_dois": [], "effect_size_source_sentence": "In contrast, inhibition of axons from the whisker-related thalamus (wTLM) and the whisker secondary somatosensory cortex (wS2) to wS1 largely attenuated the whisking-related supra- and sub-thresholddynamics of wS1 neurons." }- source_refs
[ "paper:paper-940bf3abf181" ]
- evidence_refs
[ { "ref": "paper:paper-940bf3abf181" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }