A two-layer biophysical model of mouse V1 shows that VIP-, PV-, and SST-cell mu…

A two-layer biophysical model of mouse V1 shows that VIP-, PV-, and SST-cell mutual inhibition implements bistable switches that toggle pyramidal cells between low-firing/low-frequency (SST-dominated) and high-firing/high-frequency (disinhibited) oscillatory states, with layer-specific differences in frequency and power.

{
  "n": null,
  "doi": "10.7554/elife.77594",
  "pmid": "35994330",
  "year": "2022",
  "claim": "A two-layer biophysical model of mouse V1 shows that VIP-, PV-, and SST-cell mutual inhibition implements bistable switches that toggle pyramidal cells between low-firing/low-frequency (SST-dominated) and high-firing/high-frequency (disinhibited) oscillatory states, with layer-specific differences in frequency and power.",
  "pmcid": "PMC9395191",
  "title": "Rate and oscillatory switching dynamics of a multilayer visual microcircuit model.",
  "authors": "",
  "journal": "",
  "cite_key": "Hahn2022",
  "evidence": "Rate-based and spiking computational model parameterized for L2/3 and L5 mouse V1 reproducing oscillatory state transitions.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "External drive to VIP cells increases oscillation frequency; VIP silencing only slightly raises frequency",
  "figure_data": [],
  "text_access": "fulltext",
  "study_system": "computational two-layer V1 microcircuit model (mouse)",
  "cited_by_count": 21,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "independently_replicated",
  "_source_cluster_index": 4,
  "claim_source_sentence": "Two mutual inhibitory motifs that include SST, PV, and VIP cells serve as ultrasensitive or bistable switches with different sensitivity, which can toggle the microcircuit between the two states.",
  "replication_evidence_dois": [
    "10.1016/j.neuron.2022.10.036",
    "10.1093/cercor/bhac355"
  ],
  "effect_size_source_sentence": "Both input to VIP and PV cells strongly increased the frequency of the dominant oscillation in superficial and deep layers, whereas the power of the oscillation peak generally decreased (Figure 5A–D)."
}

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]

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  {
    "ref": "paper:paper-bbc707d63f15"
  }
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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}