VIP+/calretinin+ type-3 interneuron-specific (IS3) cells in CA1 oriens/alveus s…

VIP+/calretinin+ type-3 interneuron-specific (IS3) cells in CA1 oriens/alveus selectively innervate oriens-lacunosum moleculare (OLM) cells via dendritic synapses; synchronous IS3 spikes control OLM firing rate and spike timing, implicating IS3 cells in temporal patterning of theta-rhythmic OLM output.

{
  "n": null,
  "doi": "10.1523/jneurosci.3813-13.2014",
  "pmid": "",
  "year": 2014,
  "claim": "VIP+/calretinin+ type-3 interneuron-specific (IS3) cells in CA1 oriens/alveus selectively innervate oriens-lacunosum moleculare (OLM) cells via dendritic synapses; synchronous IS3 spikes control OLM firing rate and spike timing, implicating IS3 cells in temporal patterning of theta-rhythmic OLM output.",
  "pmcid": "",
  "title": "Dendritic Inhibition Provided by Interneuron-Specific Cells Controls the Firing Rate and Timing of the Hippocampal Feedback Inhibitory Circuitry",
  "authors": "",
  "journal": "",
  "cite_key": "Tyan2014",
  "evidence": "Dual patch-clamp + targeted optogenetics in acute mouse hippocampal slices; unitary IPSC analysis at IS3-OLM synapses.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "single-spike convergent IS input controls OLM firing rate/timing",
  "figure_data": [],
  "text_access": "abstract_only",
  "study_system": "acute mouse hippocampal CA1 slices; paired patch-clamp + ChR2 optogenetics",
  "cited_by_count": 155,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "independently_replicated",
  "_source_cluster_index": 8,
  "claim_source_sentence": "Moreover, the synchronous generation of a single spike in several IS cells that converged onto a single OLM controlled the firing rate and timing of OLM interneurons.",
  "replication_evidence_dois": [
    "10.1523/jneurosci.16-10-03397.1996",
    "10.3389/fncel.2010.00130",
    "10.7554/elife.46816"
  ],
  "effect_size_source_sentence": "the synchronous generation of a single spike in several IS cells that converged onto a single OLM controlled the firing rate and timing of OLM interneurons."
}

[
  "paper:paper-6b0c417962ed"
]

[
  {
    "ref": "paper:paper-6b0c417962ed"
  }
]

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  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}