VIP disinhibitory interneurons in mouse cortex linearly scale local gamma power…

{
  "n": null,
  "doi": "10.1016/j.neuron.2022.10.036",
  "pmid": "36384143",
  "year": "2023",
  "claim": "VIP disinhibitory interneurons in mouse cortex linearly scale local gamma power without altering its stimulus tuning, while suppressing long-range gamma coherence between regions processing non-matched stimuli.",
  "pmcid": "PMC9898108",
  "title": "Cortical VIP neurons locally control the gain but globally control the coherence of gamma band rhythms.",
  "authors": "",
  "journal": "",
  "cite_key": "Veit2023",
  "evidence": "Optogenetic activation of VIP cells in mouse V1 modulates gamma power locally and inter-areal gamma coherence; computational model with VIP→SST inhibition reproduces this dual role.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "VIP cells linearly scale gamma power locally and globally tune gamma coherence between regions",
  "figure_data": [],
  "text_access": "abstract_only",
  "study_system": "mouse primary visual cortex (V1) — in vivo optogenetics + LFP, plus computational model",
  "cited_by_count": 84,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "independently_replicated",
  "_source_cluster_index": 0,
  "claim_source_sentence": "Combining electrophysiology, optogenetics, and computational modeling, we found that VIP disinhibitory interneurons in mouse cortex linearly scale gamma power locally without changing its stimulus tuning. Conversely, they suppress long-range synchronization when two regions process non-matched stimuli, tuning gamma coherence globally.",
  "replication_evidence_dois": [
    "10.1101/2021.05.20.444979",
    "10.1093/cercor/bhac355",
    "10.7554/elife.77594"
  ],
  "effect_size_source_sentence": "VIP disinhibitory interneurons in mouse cortex linearly scale gamma power locally without changing its stimulus tuning."
}

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]

Combining electrophysiology, optogenetics, and computational modeling, we found that VIP disinhibitory interneurons in mouse cortex linearly scale gamma power locally without changing its stimulus tuning. Conversely, they suppress long-range synchronization when two regions process non-matched stimuli, tuning gamma coherence globally.

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