A data-constrained mouse V1 spiking network with PV/SST/VIP cells lacks intrins…

A data-constrained mouse V1 spiking network with PV/SST/VIP cells lacks intrinsic rhythms but generates broad-band 15–60 Hz oscillations only after STDP-driven structural plasticity; feedforward inputs enhance and feedback inputs suppress these rhythms, and oscillation generation requires all four cell types.

{
  "n": null,
  "doi": "10.3389/fncom.2025.1568143",
  "pmid": "40370493",
  "year": "2025",
  "claim": "A data-constrained mouse V1 spiking network with PV/SST/VIP cells lacks intrinsic rhythms but generates broad-band 15–60 Hz oscillations only after STDP-driven structural plasticity; feedforward inputs enhance and feedback inputs suppress these rhythms, and oscillation generation requires all four cell types.",
  "pmcid": "PMC12075120",
  "title": "Synaptic plasticity facilitates oscillations in a V1 cortical column model with multiple interneuron types.",
  "authors": "",
  "journal": "",
  "cite_key": "Moreni2025b",
  "evidence": "Spiking network simulation calibrated to mouse V1 firing rates; STDP added; oscillation power evaluated.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "oscillations emerge in 15–60 Hz band only after plasticity",
  "figure_data": [],
  "text_access": "fulltext",
  "study_system": "biophysically constrained mouse V1 spiking column model",
  "cited_by_count": 5,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "single-study",
  "_source_cluster_index": 15,
  "claim_source_sentence": "The resulting model matched in vivo cell-type-specific firing rates for spontaneous and stimulus-evoked conditions in mice, although rhythmic activity was absent. Upon introduction of long-term synaptic plasticity in the form of an STDP rule, broad-band (15-60 Hz) oscillations emerged, with feedforward/feedback input streams enhancing/suppressing the oscillatory drive, respectively. These plasticity-triggered rhythms relied on all cell types, and specific experience-dependent connectivity patterns were required to generate oscillations.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "broad-band (15-60 Hz) oscillations emerged, with feedforward/feedback input streams enhancing/suppressing the oscillatory drive, respectively."
}

[
  "paper:paper-b58ecaabd35b"
]

The resulting model matched in vivo cell-type-specific firing rates for spontaneous and stimulus-evoked conditions in mice, although rhythmic activity was absent. Upon introduction of long-term synaptic plasticity in the form of an STDP rule, broad-band (15-60 Hz) oscillations emerged, with feedforward/feedback input streams enhancing/suppressing the oscillatory drive, respectively. These plasticity-triggered rhythm...

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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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