- claim_text
A detailed mouse V1 cortical-column spiking model parameterised from anatomy and electrophysiology shows that thalamocortical feedforward and cortico-cortical feedback inputs drive opposite cell-type-specific firing patterns across layers and interneuron classes, supporting layered FF/FB-dependent circuit computations.
- raw_fields
{
"n": null,
"doi": "10.1371/journal.pcbi.1012036",
"claim": "A detailed mouse V1 cortical-column spiking model parameterised from anatomy and electrophysiology shows that thalamocortical feedforward and cortico-cortical feedback inputs drive opposite cell-type-specific firing patterns across layers and interneuron classes, supporting layered FF/FB-dependent circuit computations.",
"cite_key": "Moreni2025a",
"evidence": "Anatomy- and electrophysiology-constrained spiking network model of mouse V1 column with PV/SST/VIP interneurons per laminae and AMPA/GABA/NMDA receptor dynamics.",
"effect_size": "Cell-type-specific FF/FB-driven firing pattern dichotomies replicated; FB to L1/L5 produces opposite effect on different cell classes compared to FF.",
"text_access": "abstract_only",
"study_system": "Mouse V1 cortical-column spiking model.",
"argument_role": "supporting",
"replication_status": "not_yet",
"claim_source_sentence": "We first demonstrate that thalamocortical feedforward (FF) and feedback (FB) stimuli arriving in the column have opposite effects, leading to laminar- and cell-type-specific changes in firing patterns.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": "leading to laminar- and cell-type-specific changes in firing patterns."
}- source_refs
[
"paper:paper-a3a99e8d30d7"
]
- evidence_refs
[
{
"ref": "paper:paper-a3a99e8d30d7"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}