Details
- scope
- Mice; AC, PPC, M2 cortico-cortical pathway; calcium imaging + optogenetics.
- section_id
- section_08
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json
- effect_size
- Locomotion shifts behaviour from auditory- to visual-dominance; mediated by M2-driven inhibition of AC→PPC neurons.
- review_repo
- ComputationalReviewRecurrence
- section_ref
- wiki_page:computationalreviewrecurrence-08-cross-areal
- source_kind
- review_finding
- source_path
- evidence/section_08_evidence_package.json
- source_span
- Prolonged locomotion, however, promotes visual dominance by inhibiting auditory cortical neurons projecting to the PPC (AC).
- study_system
- Mice; AC, PPC, M2 cortico-cortical pathway; calcium imaging + optogenetics.
- section_title
- 8. Cross-areal mouse cortico-cortical excitatory connectivity — hierarchical feedforward and feedback as recurrent loops at the network level; Allen Mouse Connectivity Atlas anchored views
- evidence_summary
- Circuit-specific calcium imaging + optogenetic manipulation of M2→AC→PPC pathway in mice during audiovisual conflict tasks.
- review_bundle_ref
- analysis_bundle:ab-d9c479db9be9
- replication_status
- not_yet
- review_package_ref
- analysis_bundle:ab-d9c479db9be9
- source_artifact_ref
- wiki_page:computationalreviewrecurrence-08-cross-areal
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence/blob/79ce062d54a924ce05953ec90aa9d26044d2b48f/evidence/section_08_evidence_package.json
- commit_sha
- 79ce062d54a924ce05953ec90aa9d26044d2b48f
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence
Raw fields (5)
- claim_text
Calcium imaging and optogenetic manipulation in mice show that locomotion shifts audiovisual decisions from auditory- toward visual-dominance by inhibiting an auditory-cortex→posterior parietal cortex cortico-cortical pathway via secondary motor cortex, providing a circuit-level locomotion-gating mechanism for cortico-cortical multisensory integration.
- raw_fields
{ "n": null, "doi": "10.1038/s41467-025-57347-y", "claim": "Calcium imaging and optogenetic manipulation in mice show that locomotion shifts audiovisual decisions from auditory- toward visual-dominance by inhibiting an auditory-cortex→posterior parietal cortex cortico-cortical pathway via secondary motor cortex, providing a circuit-level locomotion-gating mechanism for cortico-cortical multisensory integration.", "cite_key": "Choi2025b", "evidence": "Circuit-specific calcium imaging + optogenetic manipulation of M2→AC→PPC pathway in mice during audiovisual conflict tasks.", "effect_size": "Locomotion shifts behaviour from auditory- to visual-dominance; mediated by M2-driven inhibition of AC→PPC neurons.", "text_access": "abstract_only", "study_system": "Mice; AC, PPC, M2 cortico-cortical pathway; calcium imaging + optogenetics.", "argument_role": "supporting", "replication_status": "not_yet", "claim_source_sentence": "Prolonged locomotion, however, promotes visual dominance by inhibiting auditory cortical neurons projecting to the PPC (AC).", "source_provenance_status": "non_substring_match", "replication_evidence_dois": [], "effect_size_source_sentence": "This shift is mediated by secondary motor cortex." }- source_refs
[ "paper:paper-7a97fae6fa61" ]
- evidence_refs
[ { "ref": "paper:paper-7a97fae6fa61" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence" }