- claim_text
VIP→Martinotti and PV→Martinotti synapses have opposite short-term plasticity: PV→MC inputs show frequency-independent depression while VIP→MC inputs facilitate at high frequencies, providing temporally distinct disinhibitory motifs that interact with the irregular/bursting firing patterns of VIP cells.
- raw_fields
{
"n": null,
"doi": "10.1038/ncomms13664",
"claim": "VIP→Martinotti and PV→Martinotti synapses have opposite short-term plasticity: PV→MC inputs show frequency-independent depression while VIP→MC inputs facilitate at high frequencies, providing temporally distinct disinhibitory motifs that interact with the irregular/bursting firing patterns of VIP cells.",
"title": null,
"cite_key": "Walker2016",
"evidence": "paired patch-clamp + optogenetics in mouse S1 L2/3 (Karnani et al 2016)",
"effect_size": "PV→MC: depression; VIP→MC: facilitation at high frequencies; PV connections also stronger amplitude",
"text_access": "fulltext",
"study_system": "mouse S1 L2/3; paired recording + ChR2 optogenetics",
"_source_cluster": "cluster_04_intrinsic_electrophysiology",
"replication_status": "replicated",
"_source_cluster_index": 59,
"claim_source_sentence": "PV cell input showed frequency-independent depression, whereas VIP cell input facilitated at high frequencies.",
"replication_evidence_dois": [
"10.1038/nn.3446"
],
"effect_size_source_sentence": "Paired recordings revealed stronger synaptic input onto MC from PV cells than from VIP cells."
}- source_refs
[
"paper:paper-e93955349823"
]
- evidence_refs
[
{
"ref": "paper:paper-e93955349823"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}