Details
- scope
- mouse cortical pyramidal cells and interneurons, acute slices
- section_id
- section_05
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
- effect_size
- qualitative — close link between intrinsic ephys characteristics and transcriptome
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-05-electrophysiology
- source_kind
- review_finding
- source_path
- evidence/section_05_evidence_package.json
- source_span
- We show that Patch-seq reveals a close link between electrophysiological characteristics, responses to acute chemical challenges and RNA expression of neurotransmitter receptors and channels.
- study_system
- mouse cortical pyramidal cells and interneurons, acute slices
- section_title
- Intrinsic Electrophysiology
- evidence_summary
- mouse brain slices, somatic-aspiration scRNA-seq after patch-clamp protocol with intrinsic ephys characterisation
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replicated
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-05-electrophysiology
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
Patch-seq combines whole-cell patch-clamp electrophysiology with full-soma RNA-seq from individual cortical neurons and resolves transcriptomic subtypes that align with intrinsic electrophysiological properties, supporting transcriptome-electrophysiology mapping at single-cell resolution.
- raw_fields
{ "n": null, "doi": "10.1038/nbt.3443", "claim": "Patch-seq combines whole-cell patch-clamp electrophysiology with full-soma RNA-seq from individual cortical neurons and resolves transcriptomic subtypes that align with intrinsic electrophysiological properties, supporting transcriptome-electrophysiology mapping at single-cell resolution.", "title": null, "cite_key": "Fuzik2016", "evidence": "mouse brain slices, somatic-aspiration scRNA-seq after patch-clamp protocol with intrinsic ephys characterisation", "effect_size": "qualitative — close link between intrinsic ephys characteristics and transcriptome", "text_access": "fulltext", "study_system": "mouse cortical pyramidal cells and interneurons, acute slices", "_source_cluster": "cluster_04_intrinsic_electrophysiology", "replication_status": "replicated", "_source_cluster_index": 10, "claim_source_sentence": "We show that Patch-seq reveals a close link between electrophysiological characteristics, responses to acute chemical challenges and RNA expression of neurotransmitter receptors and channels.", "replication_evidence_dois": [ "10.1038/nbt.3445", "10.1126/science.adf6484", "10.1038/s41586-020-2907-3" ], "effect_size_source_sentence": "We show that Patch-seq reveals a close link between electrophysiological characteristics, responses to acute chemical challenges and RNA expression of neurotransmitter receptors and channels." }- source_refs
[ "paper:paper-fd924ebdd0c4" ]
- evidence_refs
[ { "ref": "paper:paper-fd924ebdd0c4" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }