Details
- scope
- rat L1 somatosensory cortex acute slices, Patch-seq
- section_id
- section_05
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
- effect_size
- n=67 L1 interneurons profiled with all three modalities; concordance between firing-pattern class and transcriptomic class qualitatively strong
- review_repo
- ComputationalReviewVIP
- section_ref
- wiki_page:computationalreviewvip-05-electrophysiology
- source_kind
- review_finding
- source_path
- evidence/section_05_evidence_package.json
- source_span
- In a separate set of experiments, we carried out patch-clamping on an additional set of 67 L1 interneurons in acute cortical slices using the Patch-seq protocol.
- study_system
- rat L1 somatosensory cortex acute slices, Patch-seq
- section_title
- Intrinsic Electrophysiology
- evidence_summary
- rat juvenile somatosensory cortex acute slices; Patch-seq workflow combining whole-cell recordings, morphology recovery, and scRNA-seq; n=67 L1 interneurons
- review_bundle_ref
- analysis_bundle:ab-2ce40c33e827
- replication_status
- replicated
- review_package_ref
- analysis_bundle:ab-2ce40c33e827
- source_artifact_ref
- wiki_page:computationalreviewvip-05-electrophysiology
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP/blob/95e761177f7d2ec565983d3307c14ec238f9677c/evidence/section_05_evidence_package.json
- commit_sha
- 95e761177f7d2ec565983d3307c14ec238f9677c
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewVIP
Raw fields (5)
- claim_text
Patch-seq enables simultaneous extraction of intrinsic electrophysiology, morphology and full transcriptome from single cortical interneurons; in 67 L1 interneurons the joint Patch-seq profile shows strong agreement between firing-pattern-based class (eNGC vs SBC) and transcriptomic class.
- raw_fields
{ "n": 67, "doi": "10.1038/nbt.3445", "claim": "Patch-seq enables simultaneous extraction of intrinsic electrophysiology, morphology and full transcriptome from single cortical interneurons; in 67 L1 interneurons the joint Patch-seq profile shows strong agreement between firing-pattern-based class (eNGC vs SBC) and transcriptomic class.", "title": null, "cite_key": "Cadwell2016", "evidence": "rat juvenile somatosensory cortex acute slices; Patch-seq workflow combining whole-cell recordings, morphology recovery, and scRNA-seq; n=67 L1 interneurons", "effect_size": "n=67 L1 interneurons profiled with all three modalities; concordance between firing-pattern class and transcriptomic class qualitatively strong", "text_access": "fulltext", "study_system": "rat L1 somatosensory cortex acute slices, Patch-seq", "_source_cluster": "cluster_04_intrinsic_electrophysiology", "replication_status": "replicated", "_source_cluster_index": 9, "claim_source_sentence": "In a separate set of experiments, we carried out patch-clamping on an additional set of 67 L1 interneurons in acute cortical slices using the Patch-seq protocol.", "replication_evidence_dois": [ "10.1038/nbt.3443", "10.1126/science.adf6484", "10.1038/s41586-020-2907-3" ], "effect_size_source_sentence": "In a separate set of experiments, we carried out patch-clamping on an additional set of 67 L1 interneurons in acute cortical slices using the Patch-seq protocol." }- source_refs
[ "paper:paper-1ce98e1d2969" ]
- evidence_refs
[ { "ref": "paper:paper-1ce98e1d2969" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP" }