Across the multimodal cell census of mouse primary motor cortex (MOp), GABAergi…

Across the multimodal cell census of mouse primary motor cortex (MOp), GABAergic neurons in cortical layers 2–6 segregate into mutually exclusive PVALB, SST and VIP molecular populations, while Pvalb and Sst are not detectable in layer 1 — anchoring the layer-specific intrinsic-property signatures of CGE-derived (VIP, Lamp5, Sncg) versus MGE-derived populations.

{
  "n": null,
  "doi": "10.1038/s41586-021-03950-0",
  "claim": "Across the multimodal cell census of mouse primary motor cortex (MOp), GABAergic neurons in cortical layers 2–6 segregate into mutually exclusive PVALB, SST and VIP molecular populations, while Pvalb and Sst are not detectable in layer 1 — anchoring the layer-specific intrinsic-property signatures of CGE-derived (VIP, Lamp5, Sncg) versus MGE-derived populations.",
  "title": null,
  "cite_key": "Braininitiativecellcensusnetworkbiccn2021",
  "evidence": "Integrated multi-omic atlas: 7 sc/snRNA-seq + snmC-seq2 + snATAC-seq datasets in mouse MOp; cross-species mapping to marmoset and human",
  "effect_size": "Three mutually exclusive subclasses (Pvalb, Sst, Vip) span L2–L6; Pvalb/Sst absent in L1",
  "text_access": "fulltext",
  "study_system": "mouse + marmoset + human primary motor cortex multimodal atlas",
  "_source_cluster": "cluster_04_intrinsic_electrophysiology",
  "replication_status": "replicated",
  "_source_cluster_index": 41,
  "claim_source_sentence": "In cortical layers 2-6, most GABAergic neurons have mutually exclusive expression of parvalbumin (PVALB), somatostatin (SST) or vasoactive intestinal peptide (VIP) 21.",
  "replication_evidence_dois": [
    "10.1038/s41586-021-03465-8",
    "10.1016/j.cell.2020.09.057"
  ],
  "effect_size_source_sentence": "In contrast, Pvalb and Sst are not expressed in mouse layer 1 by in situ hybridization (ISH)."
}

[
  "paper:paper-pm-34616075"
]

[
  {
    "ref": "paper:paper-pm-34616075"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}