Nuclear-localized GCaMP two-photon imaging in mouse V1 reveals that the salt-an…

Nuclear-localized GCaMP two-photon imaging in mouse V1 reveals that the salt-and-pepper organization of orientation tuning hides a fine-scale 'micro-clustered' organization: extremely-close-neighbour neuron pairs share strongly correlated orientation tuning while distant pairs are essentially uncorrelated, consistent with recurrent excitatory-coupling-dominated wiring rather than feedforward inheritance.

{
  "n": 0,
  "doi": "10.1101/2025.02.11.637768",
  "claim": "Nuclear-localized GCaMP two-photon imaging in mouse V1 reveals that the salt-and-pepper organization of orientation tuning hides a fine-scale 'micro-clustered' organization: extremely-close-neighbour neuron pairs share strongly correlated orientation tuning while distant pairs are essentially uncorrelated, consistent with recurrent excitatory-coupling-dominated wiring rather than feedforward inheritance.",
  "cite_key": "Yu2025",
  "evidence": "Two-photon calcium imaging in mouse V1 using a novel nuclear-localized GCaMP indicator with circuit-based recurrent network modeling.",
  "effect_size": "qualitative — short-range orientation micro-clustering hidden in classical salt-and-pepper view",
  "text_access": "fulltext",
  "study_system": "mouse primary visual cortex (V1) L2/3 in vivo",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "neuron pairs that are extremely close have strongly correlated orientation tuning, indicating a narrow yet strong spatially clustered organization of orientation preference, which we term 'micro-clustered' organization",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "we term 'micro-clustered' organization"
}

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