Single-neuron reconstruction of 6,357 mouse prefrontal cortex projection neuron…

Single-neuron reconstruction of 6,357 mouse prefrontal cortex projection neurons identifies 64 projectome-defined subtypes that map onto four major cortico-cortical subnetworks targeted by distinct PFC subtypes defined by their first-order axon collaterals.

{
  "n": 6357,
  "doi": "10.1038/s41593-022-01041-5",
  "claim": "Single-neuron reconstruction of 6,357 mouse prefrontal cortex projection neurons identifies 64 projectome-defined subtypes that map onto four major cortico-cortical subnetworks targeted by distinct PFC subtypes defined by their first-order axon collaterals.",
  "cite_key": "Gao2022",
  "evidence": "Sparse labelling + whole-brain imaging + single-neuron axon reconstruction of mouse PFC; hierarchical clustering by axon collateral targets.",
  "effect_size": "6,357 PFC projection neurons; 64 projectome subtypes; four major cortico-cortical subnetworks each targeted by a distinct group of subtypes.",
  "text_access": "abstract_only",
  "study_system": "Mouse PFC; whole-brain single-neuron axon reconstruction.",
  "argument_role": "supporting",
  "replication_status": "replicated",
  "claim_source_sentence": "Using single-neuron reconstruction of 6,357 mouse PFC projection neurons, we identified 64 projectome-defined subtypes.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [
    "10.1038/s41586-021-03941-1"
  ],
  "effect_size_source_sentence": "Each of four previously known major cortico-cortical subnetworks was targeted by a distinct group of PFC subtypes defined by their first-order axon collaterals."
}

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