Across cortico-cortical pathways, both the layer of origin and the layer of ter…

Across cortico-cortical pathways, both the layer of origin and the layer of termination plus selective targeting of distinct excitatory and inhibitory postsynaptic populations produce pathway-specific cellular and synaptic architecture in cortex — the laminar organization is the dominant principle distinguishing inter-areal pathways.

{
  "n": null,
  "doi": "10.3389/fnana.2017.00071",
  "claim": "Across cortico-cortical pathways, both the layer of origin and the layer of termination plus selective targeting of distinct excitatory and inhibitory postsynaptic populations produce pathway-specific cellular and synaptic architecture in cortex — the laminar organization is the dominant principle distinguishing inter-areal pathways.",
  "cite_key": "DSouza2017",
  "evidence": "Synthesis of laminar mapping and CRACM-style circuit-mapping studies of cortico-cortical pathways across mouse and primate cortex.",
  "effect_size": "Laminar origin/termination + cell-type selectivity defines functionally distinct inter-areal computations.",
  "text_access": "abstract_only",
  "study_system": "Review; mouse + primate cortico-cortical anatomy.",
  "argument_role": "supporting",
  "replication_status": "replicated",
  "claim_source_sentence": "By originating and terminating in different laminae, and by selectively targeting specific populations of excitatory and inhibitory neurons, these 'inter-areal' pathways are configured to perform distinct computations.",
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  "replication_evidence_dois": [
    "10.7554/eLife.100478"
  ],
  "effect_size_source_sentence": "In what ways do these pathways differ? By originating and terminating in different laminae, and by selectively targeting specific populations of excitatory and inhibitory neurons."
}

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