- claim_text
Cortical inhibitory neurons exhibit variation along transcriptomic continua that predict their intrinsic physiological properties; a single transcriptomic continuum explains a large portion of differences in state-modulation and intrinsic membrane properties across Pvalb/Sst/Vip/Lamp5/Sncg subtypes.
- raw_fields
{
"n": null,
"doi": "10.1038/s41586-022-04915-7",
"claim": "Cortical inhibitory neurons exhibit variation along transcriptomic continua that predict their intrinsic physiological properties; a single transcriptomic continuum explains a large portion of differences in state-modulation and intrinsic membrane properties across Pvalb/Sst/Vip/Lamp5/Sncg subtypes.",
"title": null,
"cite_key": "Bugeon2022",
"evidence": "in vivo two-photon Ca2+ imaging during locomotion + post-hoc transcriptomics in mouse V1; cross-referenced with Patch-seq intrinsic-property atlases",
"effect_size": "qualitative — 1-D transcriptomic axis correlates with both physiology and state-modulation",
"text_access": "fulltext",
"study_system": "mouse V1 in vivo imaging + scRNA-seq + intrinsic-property reference atlases",
"_source_cluster": "cluster_04_intrinsic_electrophysiology",
"replication_status": "replication_unknown",
"_source_cluster_index": 31,
"claim_source_sentence": "These differences in state modulation were explained in large part by a single transcriptomic continuum, which also correlated with the intrinsic membrane properties and morphology of these subtypes as assessed in vitro 7, and with their expression of excitatory and inhibitory cholinergic receptors.",
"replication_evidence_dois": [],
"effect_size_source_sentence": "These differences in state modulation were explained in large part by a single transcriptomic continuum, which also correlated with the intrinsic membrane properties and morphology of these subtypes as assessed in vitro 7."
}- source_refs
[
"paper:paper-062fda557edf"
]
- source_span
These differences in state modulation were explained in large part by a single transcriptomic continuum, which also correlated with the intrinsic membrane properties and morphology of these subtypes as assessed in vitro 7, and with their expression of excitatory and inhibitory cholinergic receptors.
- evidence_refs
[
{
"ref": "paper:paper-062fda557edf"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}