International Brain Laboratory brain-wide Neuropixels and widefield-imaging dat…

International Brain Laboratory brain-wide Neuropixels and widefield-imaging data show that mice estimate prior probabilities across visual decision-making blocks and that this subjective prior is encoded in at least 20–30% of brain regions spanning all levels of cortical processing, providing evidence for distributed cortico-cortical representation of task prior.

{
  "n": null,
  "doi": "10.1038/s41586-025-09226-1",
  "claim": "International Brain Laboratory brain-wide Neuropixels and widefield-imaging data show that mice estimate prior probabilities across visual decision-making blocks and that this subjective prior is encoded in at least 20–30% of brain regions spanning all levels of cortical processing, providing evidence for distributed cortico-cortical representation of task prior.",
  "cite_key": "Findling2025",
  "evidence": "IBL pooled Neuropixels recordings + widefield calcium imaging across mouse cortex and subcortex during a visual decision task with block-wise prior alternation.",
  "effect_size": "≥20–30% of brain regions encode subjective prior; spans cortical hierarchy.",
  "text_access": "abstract_only",
  "study_system": "Mice; IBL Neuropixels + widefield decision-making dataset.",
  "argument_role": "supporting",
  "replication_status": "not_yet",
  "claim_source_sentence": "we report that this subjective prior is encoded in at least 20% to 30% of brain regions that, notably, span all levels of processing, from early sensory to late association cortex.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "we report that this subjective prior is encoded in at least 20% to 30% of brain regions."
}

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