Nicotinic agonists selectively excite a subpopulation of neocortical GABAergic…

Nicotinic agonists selectively excite a subpopulation of neocortical GABAergic interneurons that coexpress VIP and CCK, via non-α7 nicotinic receptors containing α4/α5/β2 subunits, while pyramidal neurons, PV and SST interneurons are unresponsive.

{
  "n": null,
  "doi": "10.1523/jneurosci.19-13-05228.1999",
  "year": "1999",
  "claim": "Nicotinic agonists selectively excite a subpopulation of neocortical GABAergic interneurons that coexpress VIP and CCK, via non-α7 nicotinic receptors containing α4/α5/β2 subunits, while pyramidal neurons, PV and SST interneurons are unresponsive.",
  "title": "Selective excitation of subtypes of neocortical interneurons by nicotinic receptors",
  "journal": "",
  "species": "rat",
  "cite_key": "Porter1999",
  "evidence": "Whole-cell patch + single-cell RT-PCR in acute rat neocortical slices.",
  "effect_size": "nAChR responses persisted with α7 antagonist methyllycaconitine but were blocked by DHβE/mecamylamine; α4, α5, and β2 subunits expressed in responsive cells.",
  "text_access": "abstract_only",
  "_source_cluster": "cluster_13_neuromodulation",
  "replication_status": "independently_replicated",
  "_source_cluster_index": 4,
  "claim_source_sentence": "Nicotinic receptor agonists had no effect on pyramidal neurons and on most types of interneurons, including parvalbumin-expressing fast spiking interneurons and somatostatin-expressing interneurons, but selectively excited a subpopulation of interneurons coexpressing the neuropeptides vasoactive intestinal peptide (VIP) and cholecystokinin.",
  "replication_evidence_dois": [
    "10.1002/syn.22116",
    "10.1523/jneurosci.0115-12.2012",
    "10.1016/j.celrep.2018.03.111"
  ],
  "effect_size_source_sentence": "Single-cell RT-PCR analysis indicated that the majority of the interneurons that responded to nicotinic stimulation coexpressed the α4, α5, and β2 nicotinic receptor subunits."
}

[
  "paper:paper-5f194b747ea7"
]

Nicotinic receptor agonists had no effect on pyramidal neurons and on most types of interneurons, including parvalbumin-expressing fast spiking interneurons and somatostatin-expressing interneurons, but selectively excited a subpopulation of interneurons coexpressing the neuropeptides vasoactive intestinal peptide (VIP) and cholecystokinin.

[
  {
    "ref": "paper:paper-5f194b747ea7"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}