Excitatory neurons in layers 5 and 6 of mouse visual cortex can be categorized…

Excitatory neurons in layers 5 and 6 of mouse visual cortex can be categorized into three axonal projection modes—ipsilateral circuit connections, callosal projections, and corticofugal projections—and each projection mode may comprise multiple dendritic morphological types, indicating that projection target only partially correlates with dendritic morphology.

{
  "n": 103,
  "doi": "10.3389/fnins.2019.00912",
  "claim": "Excitatory neurons in layers 5 and 6 of mouse visual cortex can be categorized into three axonal projection modes—ipsilateral circuit connections, callosal projections, and corticofugal projections—and each projection mode may comprise multiple dendritic morphological types, indicating that projection target only partially correlates with dendritic morphology.",
  "cite_key": "Zhang2019",
  "evidence": "103 excitatory neurons in layers 5 and 6 of visual cortex were reconstructed at single-axon resolution from brain-wide imaging (BPS, 0.2 µm × 0.2 µm × 1 µm voxel) of Thy1-eYFP H-line male mice.",
  "effect_size": "103 neurons classified into 6 dendritic types and 3 projection modes; at least 2 projection modes per dendritic type except L5-tt",
  "text_access": "abstract_only",
  "study_system": "mouse visual cortex L5/L6, Thy1-eYFP H-line, brain-wide positioning system (BPS) single-neuron reconstruction",
  "argument_role": "supporting",
  "replication_status": "consistent_with_prior",
  "claim_source_sentence": "The axon projection mode only partially correlates with the apical dendrite feature.",
  "source_provenance_status": "non_substring_match",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Correlating the two types of classifications, we have found that there are at least two projection modes comprised in the former defined neuron types except for L5-tt."
}

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