- claim_text
Feedback projections from higher visual area LM (V2) to V1 modulate both geniculocortical and intracortical excitatory inputs to layer 4 cells via activation of metabotropic glutamate receptors, reducing evoked excitatory postsynaptic currents in an input-specific manner.
- raw_fields
{
"n": 0,
"doi": "10.1152/jn.01083.2012",
"claim": "Feedback projections from higher visual area LM (V2) to V1 modulate both geniculocortical and intracortical excitatory inputs to layer 4 cells via activation of metabotropic glutamate receptors, reducing evoked excitatory postsynaptic currents in an input-specific manner.",
"cite_key": "DePasquale2013",
"evidence": "Mouse brain slice preparation studying feedback projections from higher visual areas (LM/V2) to V1 layer 4 cells using electrophysiological recordings of evoked EPSCs.",
"effect_size": "",
"text_access": "abstract_only",
"study_system": "mouse V1-LM brain slice electrophysiology",
"argument_role": "supporting",
"replication_status": "novel",
"claim_source_sentence": "We found that activation of metabotropic glutamate receptors (mGluRs) from stimulation of the feedback projection reduced the evoked excitatory postsynaptic currents of both of these inputs to layer 4 but that this modulation acts in an input-specific way.",
"source_provenance_status": "non_substring_match",
"replication_evidence_dois": [],
"effect_size_source_sentence": ""
}- source_refs
[
"paper:paper-675c85c9f3bc"
]
- source_span
We found that activation of metabotropic glutamate receptors (mGluRs) from stimulation of the feedback projection reduced the evoked excitatory postsynaptic currents of both of these inputs to layer 4 but that this modulation acts in an input-specific way.
- evidence_refs
[
{
"ref": "paper:paper-675c85c9f3bc"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}