Pathway-specific eOPN3 silencing of inputs to whisker primary somatosensory cor…

Pathway-specific eOPN3 silencing of inputs to whisker primary somatosensory cortex (wS1) in awake mice shows that inhibition of inputs from whisker secondary somatosensory cortex (wS2) substantially reduces movement-related wS1 activity while leaving whisking-variable tuning intact, dissociating the interareal contributions underlying subthreshold and suprathreshold whisking-related activity.

{
  "n": 0,
  "doi": "10.1523/jneurosci.1148-23.2023",
  "claim": "Pathway-specific eOPN3 silencing of inputs to whisker primary somatosensory cortex (wS1) in awake mice shows that inhibition of inputs from whisker secondary somatosensory cortex (wS2) substantially reduces movement-related wS1 activity while leaving whisking-variable tuning intact, dissociating the interareal contributions underlying subthreshold and suprathreshold whisking-related activity.",
  "cite_key": "Kawatani2024",
  "evidence": "In vivo whole-cell + pathway-specific opsin silencing in awake mouse cortex — directly addresses cluster_14 subthreshold + interareal scope.",
  "effect_size": null,
  "text_access": "fulltext",
  "study_system": "Awake male mice; wS1 whole-cell + axon-terminal silencing of wTLM/wM1/wS2",
  "argument_role": "supporting",
  "replication_status": "single-study",
  "claim_source_sentence": "Furthermore, we make a novel observation that inhibiting inputs from the whisker secondary somatosensory cortex (wS2) substantially curtails movement-related activities in wS1, leaving the tuning to whisking variables unaffected.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": null
}

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