Mouse V1 layer 2/3 and 5 axons arborizing in higher visual areas AL and PM carr…

Mouse V1 layer 2/3 and 5 axons arborizing in higher visual areas AL and PM carry feature-tuning distributions that match each target area's preference, demonstrating that intracortical long-range projections from V1 are functionally target-specific.

{
  "n": 0,
  "doi": "10.1038/nn.3300",
  "claim": "Mouse V1 layer 2/3 and 5 axons arborizing in higher visual areas AL and PM carry feature-tuning distributions that match each target area's preference, demonstrating that intracortical long-range projections from V1 are functionally target-specific.",
  "cite_key": "Glickfeld2013",
  "evidence": "Two-photon calcium imaging of GCaMP-labeled V1 axonal arbors in HVAs AL, PM and LM in awake mice during spatial/temporal frequency drifting gratings; axon-bouton response distributions compared with V1 somatic distributions.",
  "effect_size": "AL axons biased to high temporal, low spatial frequency; PM axons biased to low temporal, high spatial frequency",
  "text_access": "fulltext",
  "study_system": "mouse visual cortex, V1 → AL/PM/LM long-range projections, in vivo two-photon axon imaging, awake",
  "argument_role": "supporting",
  "replication_status": "independently_replicated",
  "claim_source_sentence": "We found a marked target specificity of these projections, whereby each higher visual area receives functionally distinct sensory input from layers 2/3 and 5 of V1.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1002/cne.70111"
  ],
  "effect_size_source_sentence": "Neurons in AL respond best to stimuli with high temporal and low spatial frequencies (that is, quickly moving, coarse stimuli), whereas those in PM respond best to stimuli with low temporal and high spatial frequencies (that is, slowly moving, fine stimuli)."
}

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]

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