VIP-expressing interneurons split into transcriptionally and morphologically di…

VIP-expressing interneurons split into transcriptionally and morphologically distinct sub-populations: classic bipolar VIP+ cells (vertically oriented axons) form one cluster, while multipolar VIP+/CCK+ cells are basket cells transcriptionally closer to other CCK+ baskets lacking VIP, with VIP+/CCK+ baskets enriched in supragranular layers and CCK+/VIP- baskets enriched in L5/6.

{
  "n": null,
  "doi": "10.1016/j.neuron.2018.10.009",
  "claim": "VIP-expressing interneurons split into transcriptionally and morphologically distinct sub-populations: classic bipolar VIP+ cells (vertically oriented axons) form one cluster, while multipolar VIP+/CCK+ cells are basket cells transcriptionally closer to other CCK+ baskets lacking VIP, with VIP+/CCK+ baskets enriched in supragranular layers and CCK+/VIP- baskets enriched in L5/6.",
  "title": null,
  "cite_key": "Lim2018",
  "evidence": "review of Lim 2018 + He 2016 + Tasic 2017 transcriptomic and morphological studies",
  "effect_size": "qualitative laminar enrichment differences",
  "text_access": "fulltext",
  "study_system": "review of mouse cortex VIP/CCK studies",
  "_source_cluster": "cluster_04_intrinsic_electrophysiology",
  "replication_status": "replicated",
  "_source_cluster_index": 64,
  "claim_source_sentence": "CCK+ basket cells that co-express VIP have a small soma and are particularly abundant in supragranular layers of the cortex, whereas CCK+ basket cells lacking VIP are enriched in layers 5 and 6.",
  "replication_evidence_dois": [
    "10.1038/s41586-018-0654-5",
    "10.1016/j.cell.2020.09.057"
  ],
  "effect_size_source_sentence": "Multipolar VIP+ cells are transcriptionally very different from bipolar interneurons."
}

[
  "paper:paper-11e0bb0a904f"
]

[
  {
    "ref": "paper:paper-11e0bb0a904f"
  }
]

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}