- claim_text
Three non-overlapping cortical interneuron populations — PV, SOM and VIP — collectively account for ~85% of neocortical inhibitory neurons, with VIP cells dispensing local disinhibition through a network motif that is partially constrained by their relatively few but specific local pyramidal-cell drivers.
- raw_fields
{
"n": null,
"doi": "10.1016/j.neuron.2016.02.037",
"claim": "Three non-overlapping cortical interneuron populations — PV, SOM and VIP — collectively account for ~85% of neocortical inhibitory neurons, with VIP cells dispensing local disinhibition through a network motif that is partially constrained by their relatively few but specific local pyramidal-cell drivers.",
"title": null,
"cite_key": "Karnani2016a",
"evidence": "in vivo two-photon Ca2+ imaging in mouse V1 with Cre-driven labeling of PV/SOM/VIP",
"effect_size": "PV+SOM+VIP ≈ 85% of cortical INs",
"text_access": "fulltext",
"study_system": "mouse V1 in vivo + cited literature",
"_source_cluster": "cluster_04_intrinsic_electrophysiology",
"replication_status": "replicated",
"_source_cluster_index": 44,
"claim_source_sentence": "PVs, together with somatostatin expressing cells (SOMs) and vasoactive intestinal peptide expressing cells (VIPs) form three non-overlapping populations that account for ~85% of neocortical INs (Rudy et al., 2011), and have partially dissociable roles in neural computations.",
"replication_evidence_dois": [
"10.1002/dneu.20853",
"10.1016/j.neuron.2016.06.033"
],
"effect_size_source_sentence": "PVs, together with somatostatin expressing cells (SOMs) and vasoactive intestinal peptide expressing cells (VIPs) form three non-overlapping populations that account for ~85% of neocortical INs."
}- source_refs
[
"paper:paper-d405e5906927"
]
- source_span
PVs, together with somatostatin expressing cells (SOMs) and vasoactive intestinal peptide expressing cells (VIPs) form three non-overlapping populations that account for ~85% of neocortical INs (Rudy et al., 2011), and have partially dissociable roles in neural computations.
- evidence_refs
[
{
"ref": "paper:paper-d405e5906927"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
}