Whole-cell recordings combined with optogenetic stimulation of V1 axons in vitr…

Whole-cell recordings combined with optogenetic stimulation of V1 axons in vitro reveal area-specific differences in the strength with which feedforward V1 inputs and within-area recurrent pathways recruit interneurons across mouse higher visual areas LM, AL, PM and AM.

{
  "n": 4,
  "doi": "10.1016/j.cub.2021.09.042",
  "claim": "Whole-cell recordings combined with optogenetic stimulation of V1 axons in vitro reveal area-specific differences in the strength with which feedforward V1 inputs and within-area recurrent pathways recruit interneurons across mouse higher visual areas LM, AL, PM and AM.",
  "cite_key": "Li2021a",
  "evidence": "In-vitro whole-cell recordings from neurons in HVAs (LM, AL, PM, AM) of mouse cortex with optogenetic activation of V1 axons in slice.",
  "effect_size": "HVA-specific differences in V1-driven excitatory and inhibitory recruitment across LM, AL, PM, AM.",
  "text_access": "fulltext",
  "study_system": "Mouse acute slice; whole-cell recording from HVAs with optogenetic V1-axon activation.",
  "argument_role": "supporting",
  "replication_status": "replicated",
  "claim_source_sentence": "We discovered area-specific differences in the strength of recruitment of interneurons through feedforward and recurrent pathways, as well as differences in cell-class-specific recruitment.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [
    "10.1038/s41586-019-1716-z"
  ],
  "effect_size_source_sentence": "Here, we sought to determine whether higher order visual cortical areas lateromedial (LM), anterolateral (AL), posteromedial (PM), and anteromedial (AM) have specialized anatomical and physiological properties."
}

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