Mouse VISp neurons partition into 17 distinct intrinsic electrophysiological ty…

Mouse VISp neurons partition into 17 distinct intrinsic electrophysiological types (e-types) that differ across firing-pattern descriptors (adapting, irregular, transient), AP shape, subthreshold properties (membrane time constant, sag), and f–I curve location/shape.

{
  "n": null,
  "doi": "10.1038/s41593-019-0417-0",
  "claim": "Mouse VISp neurons partition into 17 distinct intrinsic electrophysiological types (e-types) that differ across firing-pattern descriptors (adapting, irregular, transient), AP shape, subthreshold properties (membrane time constant, sag), and f–I curve location/shape.",
  "title": null,
  "cite_key": "Gouwens2019",
  "evidence": "standardized current-clamp recordings of >1,800 mouse VISp neurons; unsupervised clustering on AP and f–I features",
  "effect_size": "17 e-types identified",
  "text_access": "fulltext",
  "study_system": "mouse VISp; standardized intracellular recordings + biocytin reconstruction",
  "_source_cluster": "cluster_04_intrinsic_electrophysiology",
  "replication_status": "replicated",
  "_source_cluster_index": 30,
  "claim_source_sentence": "Specific e-types differed from each other across a variety of characteristics, including firing patterns (e.g., adapting, irregular, transient), AP shape, subthreshold properties (membrane time constant, sag), and f-I curve location and shape.",
  "replication_evidence_dois": [
    "10.1016/j.cell.2020.09.057"
  ],
  "effect_size_source_sentence": "We next examined basic electrophysiological characteristics of the 17 identified e-types, such as the AP shape, the estimated membrane capacitance and input resistance, the average f-I curve, and the coefficient of variation of the ISI durations (CV ISI, Fig."
}

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]

Specific e-types differed from each other across a variety of characteristics, including firing patterns (e.g., adapting, irregular, transient), AP shape, subthreshold properties (membrane time constant, sag), and f-I curve location and shape.

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