Knowledge gaps
Open scientific unknowns surfaced from the literature, debates, and landscapes — each a candidate for a bounty challenge. Click any gap to see its funding status or promote it to a market.
Sorted by Composite score.
- What determines the specificity of RNA-protein interactions that drive distinct…gap-pubmed-20260406-041428-53b81741
- How do tau and MAP6 spatially segregate on individual microtubules during axona…gap-pubmed-20260410-100456-241a1d06
- Why do in vitro and non-neuronal cell studies show tau as a microtubule stabili…gap-pubmed-20260410-100455-a6cfc136
- What makes certain neuronal populations vulnerable to 90% loss while others are…gap-pubmed-20260411-071347-7d5563c5
- How do tau and MAP6 balance morphological stability with plasticity beyond micr…gap-pubmed-20260410-100445-e74c0492
- How do retinal tau pathology patterns compare to brain tau pathology in the sam…gap-pubmed-20260411-073329-b486d504
- How does IDH2 gain-of-function mechanistically stabilize HIF-1α through reducti…gap-pubmed-20260410-155404-c8155a18
- How does AQP4 inhibition mechanistically reverse the no-reflow phenomenon in is…gap-pubmed-20260410-164516-228f1a68
- Does SPP1-mediated synaptic engulfment represent beneficial clearance or pathol…gap-pubmed-20260406-062118-2cdbb0dd
- Does TFEB activation directly restore mutant GBA enzyme activity or only enhanc…gap-debate-20260410-100423-78eecb9f
- How does SARS-CoV-2 infection lead to future neurodegeneration as a long-term c…gap-pubmed-20260411-070339-d587cce6
- What causes poor brain penetration and target engagement of anti-TREM2 antibodi…gap-debate-20260410-100406-09a33644
- What are the genuine microtubule stabilizers that tau outcompetes in axons?gap-pubmed-20260410-100501-6c339b30
- How does 3BP2 adaptor protein function as a target of Syk in neurological conte…gap-pubmed-20260410-192457-fe472d5d
- How do microglial activation states beyond M1/M2 respond to gut-derived metabol…gap-debate-20260410-095529-9d1cc5db
- Why does plasma p-tau181 show stronger correlation with amyloid than tau pathol…gap-pubmed-20260410-150600-ff4e805a
- Which specific post-translational modifications create druggable epitopes uniqu…gap-debate-20260410-100357-76f5b31e
- What paracrine factors mediate ARAP3-dependent microglial-astrocyte crosstalk a…gap-debate-20260410-100422-83631bc7
- Which specific GBA mutations retain sufficient residual enzyme function to bene…gap-debate-20260410-100423-38a86026
- Can enhanced autophagy paradoxically increase α-synuclein aggregation when clea…gap-debate-20260410-100423-26c12e9c
- What upstream signals activate the prosaposin-GPR37-IL-6 axis specifically in o…gap-pubmed-20260410-150500-867d3e90
- What safety margins exist for membrane-disrupting nanobodies between therapeuti…gap-debate-20260410-100359-892a3c3e
- Can astrocyte subtype transitions be reliably controlled or are they stochastic…gap-debate-20260410-100417-892fd3ab
- What are the long-term safety and efficacy profiles of circSCMH1@LNP1 treatment…gap-pubmed-20260410-192015-1c3178b4
- What is the therapeutic window between selective tau vesicle penetration and no…gap-debate-20260410-100403-fc611008
- Why do transferred mitochondria cause oxidative damage despite being metabolica…gap-pubmed-20260410-193111-e698281e
- Why do peripheral tissue TREM2 functions fail to predict brain-specific therape…gap-debate-20260410-100409-5f7c9f81
- Which paracrine factors mediate ARAP3-dependent microglial-astrocyte cross-talk…gap-debate-20260410-100417-f945c6b5
- Do bioenergetic checkpoints (ATP/ADP ratios) causally control astrocyte subtype…gap-debate-20260410-100417-898d796d
- What molecular mechanisms link age-dependent Aβ/P-Tau accumulation to reduced a…gap-pubmed-20260411-080117-cb0ab6a0
- Do GLP-1 agonists' neuroprotective effects translate from animal models to huma…gap-pubmed-20260410-213827-ff2730a0
- Do GLP-1 RAs reproducibly engage neural targets that mediate cognitive function…gap-pubmed-20260410-192609-e242219d
- How do astrocyte-neuron metabolic interactions change during disease progressio…gap-debate-20260403-222618-e6a431dd
- Which metabolic biomarkers can distinguish therapeutic response from disease pr…gap-debate-20260403-222618-c698b06a
- Why do current therapeutic approaches beyond exercise show limited efficacy in…gap-pubmed-20260410-193718-13f0ae65
- What membrane curvature changes are specifically induced by tau aggregation ver…gap-debate-20260410-100403-781ebd2b
- How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit li…gap-pubmed-20260406-041423-2d1db50c
- How can therapeutic hypotheses be systematically evaluated without comprehensiv…gap-debate-20260410-100357-4faa29ef
- How do bioenergetic checkpoints (ATP/ADP ratios) mechanistically control astroc…gap-debate-20260410-100422-5158d7cd
- What experimental approaches can validate druggability of tau epitopes in patho…gap-debate-20260410-100357-639089a1
- What are the specific molecular mechanisms linking liver failure to neuropsychi…gap-pubmed-20260411-065214-47ee317e
- What are the specific synaptic gene and protein changes caused by defective neu…gap-pubmed-20260410-150438-2a766c9b
- How do dilncRNAs specifically drive molecular crowding and phase separation of…gap-pubmed-20260406-062229-35a642ca
- Blood-brain barrier permeability changes as early biomarkers for neurodegenerat…gap-bbb-permeability-biomarker-20260426
- What molecular mechanisms explain how DGAT deletion exacerbates neurodegenerati…gap-pubmed-20260410-193303-f7f04c4f
- Mechanisms of microglial senescence in ALS: causative vs consequential rolesgap-20260426-9ef644434177
- Are tau-MAP6 interactions disrupted in tauopathies and other neurodegenerative…gap-pubmed-20260410-100456-a84ff49e