Knowledge gaps
Open scientific unknowns surfaced from the literature, debates, and landscapes — each a candidate for a bounty challenge. Click any gap to see its funding status or promote it to a market.
Showing neurodegeneration gaps, sorted by Composite score.
- What molecular mechanisms link LXRβ to oligodendrocyte maturation and gene expr…gap-pubmed-20260410-170914-ac8a4085
- What are the specific molecular mechanisms by which gut microbiota signals trav…gap-pubmed-20260410-191933-4621dc31
- How does the S209F mutation alter ABI3 phosphorylation and what are the functio…gap-pubmed-20260410-170639-493a2d1f
- What determines P2RY12 receptor expression/activity specifically in VSMCs durin…gap-pubmed-20260406-041434-a4d6154a
- What is the molecular mechanism linking cysteine oxidation to reduced protein m…gap-pubmed-20260410-170021-87f83b27
- How does disrupted MCL-1/ACSL1 interaction contribute to cardiac toxicity of MC…gap-pubmed-20260410-170301-bbbe9344
- What determines the penetrance and expressivity of protective genetic variants…gap-pubmed-20260410-105533-95280cfc
- How can the heparan-sulphate proteoglycan-APOE receptor pathway be therapeutica…gap-pubmed-20260410-105533-c52976c2
- Why does the protective TMEM106B T185S variant fail to show protection in mouse…gap-pubmed-20260410-165723-12852072
- Do GLP-1 RAs reproducibly engage neural targets that mediate cognitive function…gap-pubmed-20260410-192609-e242219d
- What determines glycocalyx-mediated selectivity for different misfolded protein…gap-debate-20260410-105449-87084bb0
- Why do current therapeutic approaches beyond exercise show limited efficacy in…gap-pubmed-20260410-193718-13f0ae65
- Which cell types show the most significant expression changes for neurodegenera…gap-debate-20260403-222543-20260402
- How do disease-associated mutations in G3BP1 or its binding partners alter stre…gap-pubmed-20260406-041428-e14e6524
- How do misfolded monomers and oligomeric intermediates cause neuronal toxicity?gap-pubmed-20260410-173351-68268f2d
- What molecular mechanisms explain how DGAT deletion exacerbates neurodegenerati…gap-pubmed-20260410-193303-f7f04c4f
- How does endothelial CD2AP loss specifically contribute to neurodegeneration ve…gap-pubmed-20260410-105517-d3e7857d
- How do PGC1α's multiple functions (mitochondrial biogenesis, ROS regulation, in…gap-pubmed-20260410-100527-afe28aec
- Do GLP-1 agonists' neuroprotective effects translate from animal models to huma…gap-pubmed-20260410-213827-ff2730a0
- How do astrocyte-neuron metabolic interactions change during disease progressio…gap-debate-20260403-222618-e6a431dd
- How does TRIM21-mediated K63 ubiquitination of G3BP1 mechanistically inhibit li…gap-pubmed-20260406-041423-2d1db50c
- Which specific post-translational modifications create druggable epitopes uniqu…gap-debate-20260410-100357-76f5b31e
- Why do transferred mitochondria cause oxidative damage despite being metabolica…gap-pubmed-20260410-193111-e698281e
- How do dilncRNAs specifically drive molecular crowding and phase separation of…gap-pubmed-20260406-062229-35a642ca
- Blood-brain barrier permeability changes as early biomarkers for neurodegenerat…gap-bbb-permeability-biomarker-20260426
- What upstream signals activate the prosaposin-GPR37-IL-6 axis specifically in o…gap-pubmed-20260410-150500-867d3e90
- Why is PGC1α expression specifically reduced in AD brains compared to other neu…gap-pubmed-20260410-100527-2ff25331
- Can astrocyte subtype transitions be reliably controlled or are they stochastic…gap-debate-20260410-100417-892fd3ab
- Why does plasma p-tau181 show stronger correlation with amyloid than tau pathol…gap-pubmed-20260410-150600-ff4e805a
- How does SARS-CoV-2 infection lead to future neurodegeneration as a long-term c…gap-pubmed-20260411-070339-d587cce6
- What molecular mechanisms link age-dependent Aβ/P-Tau accumulation to reduced a…gap-pubmed-20260411-080117-cb0ab6a0
- Can enhanced autophagy paradoxically increase α-synuclein aggregation when clea…gap-debate-20260410-100423-26c12e9c
- What are the genuine microtubule stabilizers that tau outcompetes in axons?gap-pubmed-20260410-100501-6c339b30
- How do neurodegeneration gene expression patterns in SEA-AD differ from other p…gap-debate-20260403-222549-20260402
- What makes certain neuronal populations vulnerable to 90% loss while others are…gap-pubmed-20260411-071347-7d5563c5
- Why do in vitro and non-neuronal cell studies show tau as a microtubule stabili…gap-pubmed-20260410-100455-a6cfc136
- How do retinal tau pathology patterns compare to brain tau pathology in the sam…gap-pubmed-20260411-073329-b486d504
- How do tau and MAP6 spatially segregate on individual microtubules during axona…gap-pubmed-20260410-100456-241a1d06
- What determines the specificity of RNA-protein interactions that drive distinct…gap-pubmed-20260406-041428-53b81741
- Are tau-MAP6 interactions disrupted in tauopathies and other neurodegenerative…gap-pubmed-20260410-100456-a84ff49e
- What mechanisms drive TDP-43 pathology specifically in Alzheimer's disease vers…gap-pubmed-20260406-062202-094b44bf
- How do the abundant stable and labile microtubule fractions functionally intera…gap-pubmed-20260410-100459-65a00c2d
- Which of the myriad proteins and pathways are the primary contributors to neuro…gap-pubmed-20260410-100513-5c7dbe3e
- What molecular mechanisms cause acetylated tau to specifically inhibit chaperon…gap-pubmed-20260410-165317-8c29f78c
- How do endogenous CNS ligands activate PPAR-γ pathways and what determines thei…gap-pubmed-20260410-100517-639dd92e
- What are the specific molecular mechanisms linking liver failure to neuropsychi…gap-pubmed-20260411-065214-47ee317e
- What determines the spatial organization of autophagy receptors at stress granu…gap-pubmed-20260406-041423-9c2c2ee3