In mouse V1, the brain-wide origins and proportions of long-range presynaptic i…

In mouse V1, the brain-wide origins and proportions of long-range presynaptic inputs to layer 2/3 excitatory and inhibitory neurons are highly similar, indicating that distal cortical inputs are shared across the principal cell classes in superficial V1 rather than projection-class-specific.

{
  "n": 0,
  "doi": "10.1038/s41598-021-82353-7",
  "claim": "In mouse V1, the brain-wide origins and proportions of long-range presynaptic inputs to layer 2/3 excitatory and inhibitory neurons are highly similar, indicating that distal cortical inputs are shared across the principal cell classes in superficial V1 rather than projection-class-specific.",
  "cite_key": "Brown2021",
  "evidence": "Re-analysis of brain-wide monosynaptic rabies (ΔG-rabies) input datasets onto excitatory and GABAergic L2/3 V1 starter populations, applying a hierarchical-ontology comparison method (Allen CCF) to quantify input source overlap, and contrasted with L6 ntsr1 inputs.",
  "effect_size": "Long-range input distributions onto L2/3 excitatory vs inhibitory cells largely overlap; both differ from L6 ntsr1 inputs",
  "text_access": "fulltext",
  "study_system": "mouse V1 L2/3 excitatory vs GABAergic neurons, brain-wide ΔG-rabies tracing meta-analysis",
  "argument_role": "supporting",
  "replication_status": "single_study",
  "claim_source_sentence": "Consistent with these previous studies it appears inhibitory and excitatory neurons in L2/3 of mouse V1 receive highly overlapping inputs from distal brain regions.",
  "source_provenance_status": "ok",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "It is clear from these data that L6 ntsr1-positive cells are readily distinguishable from upper layer cells based on the profile of their long-range input."
}

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Re-analysis of brain-wide monosynaptic rabies (ΔG-rabies) input datasets onto excitatory and GABAergic L2/3 V1 starter populations, applying a hierarchical-ontology comparison method (Allen CCF) to quantify input source overlap, and contrasted with L6 ntsr1 inputs.