- claim_text
In mouse V1, two-photon holographic activation of illusory-contour 'IC-encoder' L2/3 neurons recapitulates the V1 representation of illusory contours through local pattern completion, indicating that recurrent intracortical excitation broadcasts top-down inference signals within V1.
- raw_fields
{
"n": 0,
"doi": "10.1038/s41593-025-02055-5",
"claim": "In mouse V1, two-photon holographic activation of illusory-contour 'IC-encoder' L2/3 neurons recapitulates the V1 representation of illusory contours through local pattern completion, indicating that recurrent intracortical excitation broadcasts top-down inference signals within V1.",
"cite_key": "Shin2025b",
"evidence": "Multi-Neuropixels recordings, mesoscale two-photon calcium imaging, and two-photon holographic optogenetic activation of identified IC-encoder neurons in mouse V1 during illusory-contour stimuli; comparison of evoked activity to true illusory representations.",
"effect_size": "Holographic activation of small IC-encoder subset reproduces ensemble-level IC representation",
"text_access": "fulltext",
"study_system": "mouse V1, awake, two-photon all-optical + Neuropixels, illusory-contour task",
"argument_role": "supporting",
"replication_status": "independently_replicated",
"claim_source_sentence": "We found that photoactivating IC-encoders recreated IC representations within V1 L2/3 through pattern completion.",
"source_provenance_status": "ok",
"replication_evidence_dois": [
"10.1016/j.cell.2019.05.045"
],
"effect_size_source_sentence": "These results imply that neurons that encode top-down inference signals locally broadcast those signals through pattern completion."
}- source_refs
[
"paper:paper-d021eac95dc2"
]
- evidence_refs
[
{
"ref": "paper:paper-d021eac95dc2"
}
]- source_policy
{
"mode": "public_source_pointer_with_short_context",
"notes": [
"Local review repositories are read-only inputs.",
"SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
],
"source_commit_sha": "79ce062d54a924ce05953ec90aa9d26044d2b48f",
"source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewRecurrence"
}- evidence_summary
Multi-Neuropixels recordings, mesoscale two-photon calcium imaging, and two-photon holographic optogenetic activation of identified IC-encoder neurons in mouse V1 during illusory-contour stimuli; comparison of evoked activity to true illusory representations.