In a layer-2/3 V1 microcircuit model, decreasing PV population size shifts PV a…

In a layer-2/3 V1 microcircuit model, decreasing PV population size shifts PV activity to precede pyramidal activity and enhances beta and gamma oscillations, while decreasing SST shifts pyramidal-to-PV ordering and selectively impairs gamma; VIP changes alter information flow between Pyr and PV populations.

{
  "n": null,
  "doi": "10.1371/journal.pcbi.1013306",
  "pmid": "40768544",
  "year": "2025",
  "claim": "In a layer-2/3 V1 microcircuit model, decreasing PV population size shifts PV activity to precede pyramidal activity and enhances beta and gamma oscillations, while decreasing SST shifts pyramidal-to-PV ordering and selectively impairs gamma; VIP changes alter information flow between Pyr and PV populations.",
  "pmcid": "PMC12349708",
  "title": "Excitatory/inhibitory ratio disruption modulates neural synchrony and flow directions in a cortical microcircuit.",
  "authors": "",
  "journal": "",
  "cite_key": "Wagatsuma2025a",
  "evidence": "V1 layer 2/3 spiking microcircuit model; population sizes systematically varied; spectral and Granger-causality–style flow analyses.",
  "cluster_id": "cluster_09_oscillations",
  "effect_size": "PV reduction enhances beta+gamma; SST reduction impairs gamma",
  "figure_data": [],
  "text_access": "fulltext",
  "study_system": "V1 layer 2/3 spiking microcircuit computational model",
  "cited_by_count": 4,
  "_source_cluster": "cluster_09_oscillations",
  "replication_status": "independently_replicated",
  "_source_cluster_index": 19,
  "claim_source_sentence": "We find that when the E/I balance is disrupted by decreasing the PV population size, activity of the PV population precedes that of the pyramidal population, which enhances beta and gamma oscillations. Conversely, pyramidal neuronal population activity was the precursor of PV interneuron activity when the E/I imbalance was induced by decreasing the SOM population size; this preferentially impaired gamma-frequency activity.",
  "replication_evidence_dois": [
    "10.1093/cercor/bhac355",
    "10.7554/elife.77594"
  ],
  "effect_size_source_sentence": "this preferentially impaired gamma-frequency activity"
}

[
  "paper:paper-088def893fc9"
]

We find that when the E/I balance is disrupted by decreasing the PV population size, activity of the PV population precedes that of the pyramidal population, which enhances beta and gamma oscillations. Conversely, pyramidal neuronal population activity was the precursor of PV interneuron activity when the E/I imbalance was induced by decreasing the SOM population size; this preferentially impaired gamma-frequency ac...

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  "source_commit_sha": "95e761177f7d2ec565983d3307c14ec238f9677c",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewVIP"
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