Details
- scope
- mouse MGE progenitors grafted into human cortical organoids
- claim_text
- PV interneuron identity shows unexpected fate plasticity: postmitotic SST+ interneurons can upregulate PV when grafted onto human cortical models
- section_id
- section_03_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
- effect_size
- non-autonomous Pvalb differentiation with PNN formation in human cortical models
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-03
- source_kind
- review_finding
- source_path
- evidence/section_03_evidence_package.json
- source_span
- lineage-traced postmitotic Sst-positive INs upregulated Pvalb when grafted onto human cortical models
- study_system
- mouse MGE progenitors grafted into human cortical organoids
- section_title
- Developmental Origins: MGE Lineage, Specification, and Migration
- evidence_summary
- Only 3D human corticogenesis models promoted efficient PV differentiation from MGE progenitors, including formation of perineuronal nets; suggests environment can dynamically shape interneuron identity
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-03
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1016/j.isci.2025.112295", "claim": "PV interneuron identity shows unexpected fate plasticity: postmitotic SST+ interneurons can upregulate PV when grafted onto human cortical models", "evidence": "Only 3D human corticogenesis models promoted efficient PV differentiation from MGE progenitors, including formation of perineuronal nets; suggests environment can dynamically shape interneuron identity", "effect_size": "non-autonomous Pvalb differentiation with PNN formation in human cortical models", "text_access": "fulltext", "study_system": "mouse MGE progenitors grafted into human cortical organoids", "replication_status": "replication_unknown", "claim_source_sentence": "lineage-traced postmitotic Sst-positive INs upregulated Pvalb when grafted onto human cortical models", "replication_evidence_dois": [], "effect_size_source_sentence": "only 3D human corticogenesis models promoted efficient, non-autonomous Pvalb differentiation, characterized by upregulation of Pvalb maturation markers, downregulation of Sst-specific markers, and the formation of perineuronal nets" }- source_refs
[ "paper:paper-de3aae7294f5" ]
- evidence_refs
[ { "ref": "paper:paper-de3aae7294f5" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }