Details
- scope
- human pluripotent stem cell organoids and assembloids
- claim_text
- MeCP2 deficiency leads to overproduction of cortical interneurons with hypermotile tangential migration dynamics and persistent hypersynchronous network activity
- section_id
- section_03_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
- effect_size
- overproduction of cortical interneurons with hypermotile tangential migration
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-03
- source_kind
- review_finding
- source_path
- evidence/section_03_evidence_package.json
- source_span
- MeCP2 deficiency also led to an overproduction of cortical interneurons (cINs), with these cINs exhibiting hypermotile tangential migration dynamics and contributing to persistent hypersynchronous network activity in assembloids.
- study_system
- human pluripotent stem cell organoids and assembloids
- section_title
- Developmental Origins: MGE Lineage, Specification, and Migration
- evidence_summary
- Human cerebral organoid/assembloid model of Rett syndrome; MeCP2 loss causes increased interneuron production and aberrant migration, not decreased as might be expected
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-03
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1016/j.celrep.2025.116670", "claim": "MeCP2 deficiency leads to overproduction of cortical interneurons with hypermotile tangential migration dynamics and persistent hypersynchronous network activity", "evidence": "Human cerebral organoid/assembloid model of Rett syndrome; MeCP2 loss causes increased interneuron production and aberrant migration, not decreased as might be expected", "effect_size": "overproduction of cortical interneurons with hypermotile tangential migration", "text_access": "fulltext", "study_system": "human pluripotent stem cell organoids and assembloids", "replication_status": "replication_unknown", "claim_source_sentence": "MeCP2 deficiency also led to an overproduction of cortical interneurons (cINs), with these cINs exhibiting hypermotile tangential migration dynamics and contributing to persistent hypersynchronous network activity in assembloids.", "replication_evidence_dois": [], "effect_size_source_sentence": "MeCP2 deficiency also led to an overproduction of cortical interneurons (cINs), with these cINs exhibiting hypermotile tangential migration dynamics" }- source_refs
[ "paper:paper-708809fbfd02" ]
- evidence_refs
[ { "ref": "paper:paper-708809fbfd02" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }