Details
- scope
- mouse, RAS/MAPK gain-of-function mutants
- claim_text
- Hyperactive RAS/MAPK signaling biases developing cortical interneurons toward somatostatin-positive fate, which can be prevented by pharmacological MAPK pathway inhibition
- section_id
- section_03_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
- effect_size
- increased SST-positive interneurons in RAS/MAPK mutants
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-03
- source_kind
- review_finding
- source_path
- evidence/section_03_evidence_package.json
- source_span
- hyperactive RAS/MAPK mutants bias developing cortical interneurons towards those that are somatostatin positive
- study_system
- mouse, RAS/MAPK gain-of-function mutants
- section_title
- Developmental Origins: MGE Lineage, Specification, and Migration
- evidence_summary
- Two distinct RAS/MAPK hyperactivating mutations converge on common GABAergic programs; increase in SST+ interneurons preventable by pharmacological inhibition
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-03
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1242/dev.201371", "claim": "Hyperactive RAS/MAPK signaling biases developing cortical interneurons toward somatostatin-positive fate, which can be prevented by pharmacological MAPK pathway inhibition", "evidence": "Two distinct RAS/MAPK hyperactivating mutations converge on common GABAergic programs; increase in SST+ interneurons preventable by pharmacological inhibition", "effect_size": "increased SST-positive interneurons in RAS/MAPK mutants", "text_access": "fulltext", "study_system": "mouse, RAS/MAPK gain-of-function mutants", "replication_status": "replication_unknown", "claim_source_sentence": "hyperactive RAS/MAPK mutants bias developing cortical interneurons towards those that are somatostatin positive", "replication_evidence_dois": [], "effect_size_source_sentence": "hyperactive RAS/MAPK mutants bias developing cortical interneurons towards those that are somatostatin positive. The increase in somatostatin-positive interneurons could also be prevented by pharmacological inhibition of the core RAS/MAPK signaling pathway." }- source_refs
[ "paper:paper-1282739b5685" ]
- evidence_refs
[ { "ref": "paper:paper-1282739b5685" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }