HIF1/2a signaling in MGE regulates Lhx6+ interneuron precursor proliferation an…

Details

scope: mouse, HIF1/2a conditional knockout in Nkx2.1 lineage
claim_text: HIF1/2a signaling in MGE regulates Lhx6+ interneuron precursor proliferation and PV interneuron production via direct activation of GRIN2B
section_id: section_03_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
effect_size: decreased numbers of parvalbumin (PV) interneurons and fewer GABAergic synapses in adult HIF1 cKO cortex
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-03
source_kind: review_finding
source_path: evidence/section_03_evidence_package.json
source_span: Nkx2.1-cre-driven conditional deletion of Hif1/2a in the medial ganglionic eminence (MGE) leads to reduced proliferation of Lhx6-positive interneuron precursors
study_system: mouse, HIF1/2a conditional knockout in Nkx2.1 lineage
section_title: Developmental Origins: MGE Lineage, Specification, and Migration
evidence_summary: HIF cKO cortex shows decreased PV interneurons, fewer GABAergic synapses, attenuated LTP; HIF1A directly activates GRIN2B
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-03
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 0,
  "doi": "10.1016/j.devcel.2026.01.007",
  "claim": "HIF1/2a signaling in MGE regulates Lhx6+ interneuron precursor proliferation and PV interneuron production via direct activation of GRIN2B",
  "evidence": "HIF cKO cortex shows decreased PV interneurons, fewer GABAergic synapses, attenuated LTP; HIF1A directly activates GRIN2B",
  "effect_size": "decreased numbers of parvalbumin (PV) interneurons and fewer GABAergic synapses in adult HIF1 cKO cortex",
  "text_access": "abstract_only",
  "study_system": "mouse, HIF1/2a conditional knockout in Nkx2.1 lineage",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "Nkx2.1-cre-driven conditional deletion of Hif1/2a in the medial ganglionic eminence (MGE) leads to reduced proliferation of Lhx6-positive interneuron precursors",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "In the adult HIF1 conditional knockout (cKO) cortex, we observed decreased numbers of parvalbumin (PV) interneurons and fewer GABAergic synapses and GRIN2B/Bassoon puncta on layer 2/3 excitatory neurons, resulting in attenuated long-term potentiation."
}

source_refs

[
  "paper:paper-724e5d87fa7e"
]

evidence_refs

[
  {
    "ref": "paper:paper-724e5d87fa7e"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

HIF1/2a signaling in MGE regulates Lhx6+ interneuron precursor proliferation an…

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