CTCF regulates the Lhx6/Lhx8 dichotomy in MGE, governing the choice between cor…

{
  "n": 0,
  "doi": "10.1523/jneurosci.3496-17.2018",
  "claim": "CTCF regulates the Lhx6/Lhx8 dichotomy in MGE, governing the choice between cortical interneuron and basal forebrain projection neuron fate",
  "evidence": "Loss of CTCF leads to marked reduction of PV and SST CINs with increased Lhx8+ basal forebrain projection neurons; Lhx6 reexpression rescues the phenotype",
  "effect_size": "marked reduction of CINs expressing parvalbumin and somatostatin",
  "text_access": "abstract_only",
  "study_system": "mouse, Ctcf conditional knockout in MGE",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "CTCF is required for the expression of the LIM homeodomain factor LHX6 involved in fate determination of cortical interneurons (CINs) that originate in the medial ganglionic eminence (MGE).",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "Conditional Ctcf ablation in the MGE of mice of either sex leads to delayed tangential migration, abnormal distribution of CIN in the neocortex, a marked reduction of CINs expressing parvalbumin and somatostatin (Sst), and an increased number of MGE-derived cells expressing Lhx8"
}

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]

[
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  }
]

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    "Local review repositories are read-only inputs.",
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  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
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