Details
- scope
- mouse, Nkx2-1 conditional knockout
- claim_text
- Downregulation of Nkx2-1 in postmitotic cells is necessary for cortical migration, while maintenance directs striatal migration via Neuropilin-2 regulation
- section_id
- section_03_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-03
- source_kind
- review_finding
- source_path
- evidence/section_03_evidence_package.json
- source_span
- downregulation of Nkx2-1 expression in postmitotic cells is necessary for the migration of interneurons to the cortex, whereas maintenance of Nkx2-1 expression is required for interneuron migration to the striatum.
- study_system
- mouse, Nkx2-1 conditional knockout
- section_title
- Developmental Origins: MGE Lineage, Specification, and Migration
- evidence_summary
- Nkx2-1 directly regulates Neuropilin-2 expression; this guidance receptor determines whether MGE-derived interneurons migrate to cortex or striatum
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- independently_replicated
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-03
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 0, "doi": "10.1016/j.neuron.2008.07.024", "claim": "Downregulation of Nkx2-1 in postmitotic cells is necessary for cortical migration, while maintenance directs striatal migration via Neuropilin-2 regulation", "evidence": "Nkx2-1 directly regulates Neuropilin-2 expression; this guidance receptor determines whether MGE-derived interneurons migrate to cortex or striatum", "effect_size": null, "text_access": "fulltext", "study_system": "mouse, Nkx2-1 conditional knockout", "replication_status": "independently_replicated", "claim_source_sentence": "downregulation of Nkx2-1 expression in postmitotic cells is necessary for the migration of interneurons to the cortex, whereas maintenance of Nkx2-1 expression is required for interneuron migration to the striatum.", "replication_evidence_dois": [ "10.1523/jneurosci.3496-17.2018", "10.1038/s41598-026-38316-x" ], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-74d13be6cf52" ]
- evidence_refs
[ { "ref": "paper:paper-74d13be6cf52" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }