PV-positive neurons and PNN-surrounded PV neurons increase postnatally in rat v…

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scope: rat, Wistar, visual cortex development
claim_text: PV-positive neurons and PNN-surrounded PV neurons increase postnatally in rat visual cortex and reach adult levels by postnatal week 7
section_id: section_03_evidence_package
source_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
effect_size: PV-PNN co-expression ratio significantly decreased after 4 weeks fluoxetine (chi-squared=9.03, P=0.003)
review_repo: ComputationalReviewPV
section_ref: wiki_page:computationalreviewpv-03
source_kind: review_finding
source_path: evidence/section_03_evidence_package.json
source_span: The number of PV-positive neurons and PNNs-surrounded PV neurons in the rat visual cortex increases postnatally and reaches adult levels by postnatal week 7.
study_system: rat, Wistar, visual cortex development
section_title: Developmental Origins: MGE Lineage, Specification, and Migration
evidence_summary: Quantitative developmental timeline: PV+ cell density increases gradually with visual cortex maturation (b=0.960, P<0.01); chronic fluoxetine downregulates PNNs/PV co-expression
review_bundle_ref: analysis_bundle:ab-e6261c8263e7
replication_status: replication_unknown
review_package_ref: analysis_bundle:ab-e6261c8263e7
source_artifact_ref: wiki_page:computationalreviewpv-03
origin_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
commit_sha: df9fc7e8d455b084152c9d713558dae0013cef21
created_by: persona-jerome-lecoq-gbo-neuroscience
repository_url: https://github.com/AllenNeuralDynamics/ComputationalReviewPV

Raw fields (4)

raw_fields

{
  "n": 5,
  "doi": "10.18240/ijo.2025.12.03",
  "claim": "PV-positive neurons and PNN-surrounded PV neurons increase postnatally in rat visual cortex and reach adult levels by postnatal week 7",
  "evidence": "Quantitative developmental timeline: PV+ cell density increases gradually with visual cortex maturation (b=0.960, P<0.01); chronic fluoxetine downregulates PNNs/PV co-expression",
  "effect_size": "PV-PNN co-expression ratio significantly decreased after 4 weeks fluoxetine (chi-squared=9.03, P=0.003)",
  "text_access": "fulltext",
  "study_system": "rat, Wistar, visual cortex development",
  "replication_status": "replication_unknown",
  "claim_source_sentence": "The number of PV-positive neurons and PNNs-surrounded PV neurons in the rat visual cortex increases postnatally and reaches adult levels by postnatal week 7.",
  "replication_evidence_dois": [],
  "effect_size_source_sentence": "The ratio of PV-positive cells surrounded by PNNs to total PV-positive cells (PNNs + /PV + /total PV + ) was significantly decreased in the FLX 4W group ( χ ²=9.03, P =0.003)"
}

source_refs

[
  "paper:paper-5ff194ad9010"
]

evidence_refs

[
  {
    "ref": "paper:paper-5ff194ad9010"
  }
]

source_policy

{
  "mode": "public_source_pointer_with_short_context",
  "notes": [
    "Local review repositories are read-only inputs.",
    "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose."
  ],
  "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21",
  "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV"
}

PV-positive neurons and PNN-surrounded PV neurons increase postnatally in rat v…

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