Details
- scope
- human PSC-derived, NKX2.1-GFP and MEIS2-mCherry reporter lines
- claim_text
- SHH-WNT crosstalk regulates LGE and MGE fate specification in human, and retinoic acid signaling contributes to CGE development
- section_id
- section_03_evidence_package
- source_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
- review_repo
- ComputationalReviewPV
- section_ref
- wiki_page:computationalreviewpv-03
- source_kind
- review_finding
- source_path
- evidence/section_03_evidence_package.json
- source_span
- We identified Sonic hedgehog (SHH)-WNT crosstalk in regulating LGE and MGE fate and uncovered a role for retinoic acid signaling in CGE development.
- study_system
- human PSC-derived, NKX2.1-GFP and MEIS2-mCherry reporter lines
- section_title
- Developmental Origins: MGE Lineage, Specification, and Migration
- evidence_summary
- hPSC reporter lines used to dissect morphogen gradients for human GE specification; fully defined protocols developed for generating three GE domains
- review_bundle_ref
- analysis_bundle:ab-e6261c8263e7
- replication_status
- replication_unknown
- review_package_ref
- analysis_bundle:ab-e6261c8263e7
- source_artifact_ref
- wiki_page:computationalreviewpv-03
- origin_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV/blob/df9fc7e8d455b084152c9d713558dae0013cef21/evidence/section_03_evidence_package.json
- commit_sha
- df9fc7e8d455b084152c9d713558dae0013cef21
- created_by
- persona-jerome-lecoq-gbo-neuroscience
- repository_url
- https://github.com/AllenNeuralDynamics/ComputationalReviewPV
Raw fields (4)
- raw_fields
{ "n": 3, "doi": "10.1016/j.stemcr.2023.01.010", "claim": "SHH-WNT crosstalk regulates LGE and MGE fate specification in human, and retinoic acid signaling contributes to CGE development", "evidence": "hPSC reporter lines used to dissect morphogen gradients for human GE specification; fully defined protocols developed for generating three GE domains", "effect_size": null, "text_access": "fulltext", "study_system": "human PSC-derived, NKX2.1-GFP and MEIS2-mCherry reporter lines", "replication_status": "replication_unknown", "claim_source_sentence": "We identified Sonic hedgehog (SHH)-WNT crosstalk in regulating LGE and MGE fate and uncovered a role for retinoic acid signaling in CGE development.", "replication_evidence_dois": [], "effect_size_source_sentence": null }- source_refs
[ "paper:paper-171e127cdafc" ]
- evidence_refs
[ { "ref": "paper:paper-171e127cdafc" } ]- source_policy
{ "mode": "public_source_pointer_with_short_context", "notes": [ "Local review repositories are read-only inputs.", "SciDEX stores paper metadata, structured evidence, file pointers, and short citation contexts; it does not copy full review prose." ], "source_commit_sha": "df9fc7e8d455b084152c9d713558dae0013cef21", "source_repository_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewPV" }